6280-52-0

Usage

Preparation

Preparation by Fries rearrangement of p-cresyl o-chloro-benzoate in the presence of aluminium chloride without solvent at 120° and 160°.

InChI:InChI=1/C14H11ClO2/c1-9-6-7-13(16)11(8-9)14(17)10-4-2-3-5-12(10)15/h2-8,16H,1H3

Upstream product

• 106-44-5 p-cresol 
• 2136-89-2 2-chlorobenzotrichloride 
• 609-65-4 o-chlorobenzoyl chloride 
• 118-91-2 ortho-chlorobenzoic acid 
• 10421-85-9 2-chloromandelic acid 
• 104-93-8 p-methylanizole 
• 6280-48-4 2-chloro-benzoic acid p-tolyl ester 

Downstream Products

• 6279-07-8 2-methyl-9H-xanthene 
• 5419-81-8 2-(2-chloro-benzyl)-4-methyl-phenol 
• 62666-05-1 C₁₈H₁₈ClNO₃ 
• 114330-12-0 2-(2-chloro-benzyl)-1-(3,5-dinitro-benzoyloxy)-4-methyl-benzene 
• 1578261-63-8 ethyl (N'-{2-[2-(2-chlorobenzoyl)-4-methylphenoxy]acetyl}hydrazinocarbonyl)acetate 
• 1578261-55-8 2-[2-(2-chlorobenzoyl)-4-methylphenoxy]acetohydrazide 
• 844464-76-2 ethyl [2-(2-chlorobenzoyl)-4-methylphenoxy]acetate 

Relevant academic research and scientific papers

Nickel-Catalyzed Decarbonyloxidation of 3-Aryl Benzofuran-2(3H)-ones to 2-Hydroxybenzophenones

We have developed a protocol to facilitate the nickel-catalyzed decarbonyloxidation of 3-aryl benzofuran-2(3H)-ones to 2-hydroxybenzophenones under mild conditions, which is an efficient approach for the decarbonyloxidation of lactones in organic synthesis. A diverse range of substrates can undergo C(O)-O/C(O)-C bond cleavage to generate the target products in good yields. These 2-hydroxybenzophenones can be converted into a variety of compounds via reactions such as esterification, cyclization, and reduction.

A convenient approach to the xanthone scaffold by an aqueous aromatic substitution of bromo- and iodoarenes

Unusual displacements of bromides and iodides through nucleophilic aromatic substitution reactions give a direct access to the xanthone core. This sustainable process is based on the use of water as an environmentally friendly solvent.