62803-77-4Relevant academic research and scientific papers
A Convenient Synthesis of Amidines via Cycloaddition-Decarboxylation of Isocyanates and Nitrones
Chen, Xinyi,Wu, Yijing,Zhang, Mei-Mei
, p. 1773 - 1778 (2020/06/08)
A base-promoted reaction between isocyanates and nitrones has been described, allowing an access to a variety of important functionalized amidines under mild reaction conditions. This strategy provides a convenient, effective, and scalable approach for the direct assembly of amidine compounds from simple starting materials in excellent yields.
Silver-Assisted [3 + 2] Annulation of Nitrones with Isocyanides: Synthesis of 2,3,4-Trisubstituted 1,2,4-Oxadiazolidin-5-ones
Shen, Xuanyu,Shatskiy, Andrey,Chen, Yan,K?rk?s, Markus D.,Wang, Xiang-Shan,Liu, Jian-Quan
, p. 3560 - 3567 (2020/03/04)
A silver-assisted method for [3 + 2] annulation of nitrones with isocyanides has been developed. The developed protocol allows access to a variety of 2,3,4-trisubstituted 1,2,4-oxadiazolidin-5-one derivatives as single diastereomers in good to excellent yields using silver oxide as the catalyst and molecular oxygen as the terminal oxidant. A plausible mechanism involving a nucleophilic addition/cyclization/protodeargentation/oxidation pathway is proposed on the basis of experimental results.
