628263-22-9 Usage
Uses
Used in Pharmaceutical Industry:
KM 233 is used as a selective agonist for the CB2 receptor, which has potential as an anti-glioma agent. It is particularly effective in inhibiting human U87 glioma cell proliferation in vitro with an IC50 value of 1.4 μM and significantly reducing U87 glioma tumor size in vivo at a dose of 2 mg/kg in a SCID mouse xenograft side-pocket model.
Used in Cancer Research:
KM 233 is used as a research tool to study the role of CB2 receptors in cancer cell proliferation and apoptosis. Its high binding affinity for the CB2 receptor and ability to penetrate the blood-brain barrier make it a valuable compound for investigating the potential therapeutic effects of CB2 receptor activation in glioma and other cancer types.
Check Digit Verification of cas no
The CAS Registry Mumber 628263-22-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,2,8,2,6 and 3 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 628263-22:
(8*6)+(7*2)+(6*8)+(5*2)+(4*6)+(3*3)+(2*2)+(1*2)=159
159 % 10 = 9
So 628263-22-9 is a valid CAS Registry Number.
628263-22-9Relevant academic research and scientific papers
Cannabinoid derivatives, methods of making, and use thereof
-
Page 20; Sheet 5 of 13, (2010/02/09)
1′-substituted cannabinoid derivatives of delta-8-tetrahydrocannabinol, delta-9-tetrahydrocannabinol, and delta-6a-10a-tetrahydrocannabinol that have affinity for the cannabinoid receptor type-1 (CB-1) and/or cannabinoid receptor type-2 (CB-2). Compounds
Synthesis and testing of novel phenyl substituted side-chain analogues of classical cannabinoids
Krishnamurthy, Mathangi,Ferreira, Antonio M.,Moore II, Bob M.
, p. 3487 - 3490 (2007/10/03)
A series of novel phenyl substituted side-chain analogues of classical cannabinoids were synthesized and their CB1 and CB2 binding affinities were evaluated relative to Δ8-THC and compound 2. CB1 and CB2 binding assays indicate that the dimethy
