628279-02-7

Basic information

• Product Name: N-[4-(1-Allyl-3-butyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-ylmethyl)phenyl]acetamide
• Synonyms: N-[4-(1-Allyl-3-butyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-ylmethyl)phenyl]acetamide;N-[4-[[3-Butyl-2,3,6,9-tetrahydro-2,6-dioxo-1-(2-propen-1-yl)-1H-purin-8-yl]Methyl]phenyl]acetaMide
• CAS NO: 628279-02-7
• Molecular Formula: C₂₁H₂₅N₅O₃
• Molecular Weight: 395.4549
• Product Categories: Aromatics;Bases & Related Reagents;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals
• Mol File: 628279-02-7.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.254 g/cm³
• PKA: 9.16±0.10(Predicted)
• CAS DataBase Reference: N-[4-(1-Allyl-3-butyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-ylmethyl)phenyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-(1-Allyl-3-butyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-ylmethyl)phenyl]acetamide(628279-02-7)
• EPA Substance Registry System: N-[4-(1-Allyl-3-butyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-ylmethyl)phenyl]acetamide(628279-02-7)

Safety Data

• Hazardous Substances Data: 628279-02-7(Hazardous Substances Data)

Usage

Description

N-[4-(1-Allyl-3-butyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-ylmethyl)phenyl]acetamide is a complex organic compound with a unique molecular structure. It is characterized by its allyl and butyl substituents on the purine core, which is connected to a phenyl group through an amide linkage. This molecule exhibits a diverse range of biological activities, making it a promising candidate for various pharmaceutical applications.

Uses

Used in Pharmaceutical Industry:
N-[4-(1-Allyl-3-butyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-ylmethyl)phenyl]acetamide is used as a key intermediate for the preparation of amide-substituted xanthine derivatives. These derivatives act as phosphoenolpyruvate carboxykinase (PEPCK) inhibitors, which play a crucial role in modulating gluconeogenesis. By inhibiting PEPCK, these compounds can help regulate blood glucose levels and are, therefore, valuable in the development of treatments for type 2 diabetes.

Upstream product

• 637334-84-0 3-Allyl-6-amino-1-butyl-5-nitroso-1H-pyrimidine-2,4-dione 
• 628278-99-9 3-allyl-5,6-diamino-1-butyl-1H-pyrimidine-2,4-dione 
• 628278-98-8 3-allyl-6-amino-1-butyl-1H-pyrimidine-2,4-dione 
• 53681-49-5 6-amino-1-n-butyl-1,3-dihydropyrimidine-2,4-dione 

Downstream Products

• 628279-14-1 2-(4-Acetylamino-phenyl)-N-(3-allyl-6-amino-1-butyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-acetamide 

Relevant articles and documents

AMIDE SUBSTITUTED XANTHINE DERIVATIVES WITH GLUCONEOGENESIS MODULATING ACTIVITY

The present invention is a 1,3,8 substituted xanthine derivative of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2 and R3 are as defined in the specification. Compounds of formula (I) and pharmaceutically acceptable salts or prodrugs thereof show activity as modulators of gluconeogenesis.