6283-81-4Relevant articles and documents
Amide/Ester Cross-Coupling via C-N/C-H Bond Cleavage: Synthesis of β-Ketoesters
Chen, Jiajia,Joseph, Devaneyan,Xia, Yuanzhi,Lee, Sunwoo
, p. 5943 - 5953 (2021/04/02)
Activated primary, secondary, and tertiary amides were coupled with enolizable esters in the presence of LiHMDS to obtain good yields of β-ketoesters at room temperature. Notably, this protocol provides an efficient, mild, and high chemoselectivity method
Compounds with coumarin-biphenyl skeleton, and preparation method and application of compounds
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Paragraph 0038; 0081-0082, (2019/09/14)
The invention belongs to the field of pharmaceutical chemistry, and discloses compounds with a coumarin-biphenyl skeleton, and a preparation method and application of the compounds. The compounds havefollowing structural general formulae. The preparation method of the two compounds is simple and reliable, and the total yield is 40% or above. Preliminary pharmacological experiments show that the compounds have a certain relaxation effect on an in-vitro arterial blood vessel of a rat, and can be used for development of antihypertensive drugs.
6-AMINO-2,4-DIHYDROPYRANO [2,3-C] PYRAZOLES AND METHODS OF USE
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Paragraph 0097-0099; 0102, (2018/10/25)
The present invention generally relates to 6-amino-2,4-dihydropyrano [2,3-c] pyrazoles as a ubiquitin specific protease 7 (USP7) inhibitor useful for the treatment of diseases mediated by malfunction of USP7, such as inflammation, cancer, and immunological disorders. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases mediated by malfunction of USP7, in mammals using compounds disclosed herein.