628326-12-5

Basic information

• Product Name: 4-Bromo-2-(4-methylpiperazino)benzaldehyde
• Synonyms: 4-Bromo-2-(4-methylpiperazino)benzaldehyde
• CAS NO: 628326-12-5
• Molecular Formula: C₁₂H₁₅BrN₂O
• Molecular Weight: 283.1643
• Mol File: 628326-12-5.mol

Chemical Properties

• Boiling Point: 394°C at 760 mmHg
• Flash Point: 192.1°C
• Appearance: /
• Density: 1.411g/cm³
• Vapor Pressure: 2.05E-06mmHg at 25°C
• Refractive Index: 1.605
• PKA: 7.65±0.42(Predicted)
• CAS DataBase Reference: 4-Bromo-2-(4-methylpiperazino)benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-2-(4-methylpiperazino)benzaldehyde(628326-12-5)
• EPA Substance Registry System: 4-Bromo-2-(4-methylpiperazino)benzaldehyde(628326-12-5)

Safety Data

• Hazardous Substances Data: 628326-12-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
4-Bromo-2-(4-methylpiperazino)benzaldehyde is utilized as an intermediate in the synthesis of various pharmaceuticals, leveraging its unique structural attributes to contribute to the development of new drugs and biologically active molecules.
Used in Organic Chemistry:
In the realm of organic chemistry, 4-Bromo-2-(4-methylpiperazino)benzaldehyde is employed as a key component in the creation of complex organic compounds, facilitating the advancement of chemical research and the discovery of new chemical entities.
Used in Medicinal Chemistry:
4-Bromo-2-(4-methylpiperazino)benzaldehyde is used as a precursor in medicinal chemistry for the design and synthesis of new therapeutic agents, capitalizing on its pharmacological properties to enhance drug discovery efforts.
Used in Antifungal Applications:
4-Bromo-2-(4-methylpiperazino)benzaldehyde is applied as an antifungal agent, harnessing its inherent antifungal activities to combat fungal infections and contribute to the development of antifungal medications.
Used in Anti-Inflammatory Applications:
4-Bromo-2-(4-methylpiperazino)benzaldehyde is also used in anti-inflammatory applications, where its anti-inflammatory properties are leveraged to alleviate inflammation and potentially contribute to the treatment of inflammatory conditions.

InChI:InChI=1/C12H15BrN2O/c1-14-4-6-15(7-5-14)12-8-11(13)3-2-10(12)9-16/h2-3,8-9H,4-7H2,1H3

Upstream product

• 109-01-3 1-methyl-piperazine 
• 57848-46-1 4-bromo-2-fluorobenzaldehyde 

Downstream Products

• 850789-65-0 3-(4-methylpiperazin-1-yl)biphenyl-4-carbaldehyde 

Relevant articles and documents

Ruthenium catalyzed β-C(sp3)-H functionalization on the 'privileged' piperazine nucleus

β-C(sp3)-H functionalization on the 'privileged' piperazine nucleus has been disclosed using ruthenium catalysis. The ruthenium catalyzed synthesis of a variety of piperazine fused indoles from ortho-piperazinyl (hetero)aryl aldehydes is presented. This transformation takes place via the dehydrogenation of piperazine followed by an intramolecular nucleophilic addition of the transient enamine moiety onto the carbonyl group and aromatization cascade.

Cationic chalcone antibiotics. Design, synthesis, and mechanism of action

This paper describes how the introduction of "cationic" aliphatic amino groups in the chalcone scaffold results in potent antibacterial compounds. It is shown that the most favorable position for the aliphatic amino group is the 2-position of the B-ring, in particular in combination with a lipophilic substituent in the 5-position of the B-ring. We demonstrate that the compounds act by unselective disruption of cell membranes. Introduction of an additional aliphatic amino group in the á-ring results in compounds that are selective for bacterial membranes combined with a high antibacterial activity against both Gram-positive and -negative pathogens. The most potent compound in this study (78) has an MIC value of 2 μM against methicillin resistant Staphylococus aureus.