62845-09-4Relevant articles and documents
Design, Synthesis and Anticancer Evaluation of New 7-O-Alkylation Genistein Derivatives
Ren, Yuyan,Chen, Hongfei,Yao, Xu,Yang, Zehua,Wu, Tingjuan,Guo, Yu,Xiao, Junhui,Zheng, Xing
, p. 924 - 931 (2020/12/09)
Genistein is a phytoestrogen compound which possesses multiple biological activities such as anti-cancer, while its application is limited by poor pharmacokinetic properties. Structural modification is an effective approach to get genistein derivatives wi
Iodine-containing genistein derivative and preparation method and application thereof
-
Paragraph 0064; 0065; 0093; 0094, (2017/08/27)
The invention discloses application of an iodine-containing genistein derivative like 4'-iodine lignin, 5,7-dimethoxy-4'-iodine lignin and 7-ethyoxyl-4'-iodine lignin in preparing an anti-radiation-injury medicine. In-vivo and in-vitro experiment results prove that the iodine-containing genistein derivative has the advantage of being small in toxic and side effects, when an effective dose for preventing radiation injury is used, weight is not reduced and system toxic reactions are not caused, and the derivative can be prepared into medicines to be taken by people working in a radiation environment and tumor radiotherapy patients. The invention relates to preparation of the anti-radiation-injury medicine which is expected to be a medicine for preventing and treating radiation injuries in clinical practice.
Mixed Anhydride of Acetic and Formic Acids in the Synthesis of Chromones. 2. Synthesis of 3-Arylchromones
Pivovarenko, V. G.,Khilya, V. P.
, p. 497 - 502 (2007/10/02)
A study was carried out on the reaction of α-substituted 2-hydroxyacetophenones eith the mixed anhydride of acetic and formic acids in the presence of bases of different strength.Chromones containing a conjugated electron-withdrawing substituent at C(3) are formed in close to quantitative yield in the presence of triethylamine.The preparation of chromones containing an unconjugated substituent under these conditions is recommended only for 5-hydroxychromones.