6285-79-6

Usage

Applications

Used in research and pharmaceutical applications.
Functions as a fluorescent probe for studying protein-protein interactions.
Investigated for potential therapeutic properties, including anti-tumor and anti-inflammatory activities.

Pharmacological Properties

Influence of the 4-methoxyphenyl group on pharmacokinetics and pharmacodynamics.

Significance

Interest in drug development and medicinal chemistry studies due to its pharmacological properties.

Upstream product

• 824-94-2 p-methoxybenzyl chloride 
• 2859-55-4 4-(4-methoxy-styryl)-quinoline 
• 491-35-0 C₆H₄NCH₂CHCCH₂ 
• 19343-78-3 4-methyl-1,2,3,4-tetrahydroquinoline 
• 105-13-5 4-Methoxybenzyl alcohol 

Relevant academic research and scientific papers

Nickel-Catalyzed Dehydrogenation of N-Heterocycles Using Molecular Oxygen

Herein, an efficient and selective nickel-catalyzed dehydrogenation of five- and six-membered N-heterocycles is presented. The transformation occurs in the presence of alkyl, alkoxy, chloro, free hydroxyl and primary amine, internal and terminal olefin, trifluoromethyl, and ester functional groups. Synthesis of an important ligand and the antimalarial drug quinine is demonstrated. Mechanistic studies revealed that the cyclic imine serves as the key intermediate for this stepwise transformation.

Iron-catalysed alkylation of 2-methyl and 4-methyl azaarenes with alcoholsviaC-H bond activation

The first Fe-catalysed alkylation of 2-methyl and 4-methyl-azaarenes with a series of alkyl and hetero-aryl alcohols is reported (>39 examples and up to 95% yield). Multi-functionalisation of pyrazines and synthesis of anti-malarial drug (±) Angustureine significantly broaden the scope of this methodology. Preliminary mechanistic investigation, deuterium labeling and kinetic experiments including trapping of the enamine intermediate1a'are of special importance.