628692-15-9

Basic information

• Product Name: 2-Methoxypyrimidine-5-boronic acid
• Synonyms: 2-METHOXY-5-PYRIMIDINEBORONIC ACID;2-METHOXYPYRIMIDIN-5-YLBORONIC ACID;2-METHOXYPYRIMIDINE-5-BORONIC ACID;2-METHOXYL-5-PYRIMIDYLBORIC ACID;2-Methoxypyrimidine-5-boronic acid ,98%;Boronic acid, B-(2-methoxy-5-pyrimidinyl)-;19 2-Methoxy Pyrimidine boronic acid;2-Methoxy PyriMidine boronic acid
• CAS NO: 628692-15-9
• Molecular Formula: C₅H₇BN₂O₃
• Molecular Weight: 153.93
• EINECS: 1592732-453-0
• Product Categories: Boronic acid;Organoborons;Pyrimidine;Boronate Ester;Potassium Trifluoroborate
• Mol File: 628692-15-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 161°C(lit.)
• Boiling Point: 378.305 °C at 760 mmHg
• Flash Point: 182.593 °C
• Appearance: /
• Density: 1.335 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.523
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 5.59±0.11(Predicted)
• CAS DataBase Reference: 2-Methoxypyrimidine-5-boronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methoxypyrimidine-5-boronic acid(628692-15-9)
• EPA Substance Registry System: 2-Methoxypyrimidine-5-boronic acid(628692-15-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36-41-36/37/38
• Safety Statements: 26-39-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 628692-15-9(Hazardous Substances Data)

Usage

Chemical Properties

Off-white to light yellow solid

InChI:InChI=1/C5H7BN2O3/c1-11-5-7-2-4(3-8-5)6(9)10/h2-3,9-10H,1H3

Upstream product

• 121-43-7 Trimethyl borate 
• 14001-66-2 5-bromo-2-methoxypyrimidine 

Downstream Products

• 1205685-03-5 5-{[1-(2-chloro-3-fluoro-4-methoxyphenyl)-2-(methoxymethyl)-3,3,3-trifluoro-2-hydroxypropyl]amino}-7-fluoro-1-(2-methoxypyrimidine-5-yl)-1H-quinolin-2-one 
• 1254567-36-6 (3-amino-2,6-difluoro-phenyl)-[5-(2-methoxy-pyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-methanone 
• 1435972-33-0 C₂₄H₂₈N₆O₄ 
• 1621525-47-0 5-(3-iodo-1H-pyrazol-1-yl)-2-methoxypyrimidine 
• 1312477-65-8 (2R)-N-hydroxy-4-{4-[4-(2-methoxypyrimidin-5-yl)phenyl]-2-oxopyridin-1(2H)-yl}-2-methyl-2-(methylsulfonyl)butanamide 
• 1358778-95-6 (2R)-4-{4-[4-(2-methoxypyrimidin-5-yl)phenyl]-2-oxopyridin-1(2H)-yl}-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide 
• 1358778-94-5 2-methoxy-5-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]pyrimidine 
• 27956-15-6 5-(4-bromophenyl)-2-methoxypyrimidine 

Relevant articles and documents

Flow Chemistry on Multigram Scale: Continuous Synthesis of Boronic Acids within 1 s

The benefits and limitations of a simple continuous flow setup for handling and performing of organolithium chemistry on the multigram scale is described. The developed metalation platform embodies a valuable complement to existing methodologies, as it combines the benefits of Flash Chemistry (chemical synthesis on a time scale of 1 s) with remarkable throughput (g/min) while mitigating the risk of blockages.

Efficient hydrolysis of organotrifluoroborates via silica gel and water

(Chemical Equation Presented) A general, mild, and efficient method for the hydrolysis of organotrifluoroborates to unveil boronic acids using silica gel and H2O was developed. This method proved to be tolerant of a broad range of aryl-, heteroaryl-, alkenyl-, and alkyltrifluoroborates as well as structurally diverse aminomethylated organotrifluoroborates.As anticipated, electron-rich substrates provided the corresponding boronic acids more readily than electron-poor substrates, owing to the resonance-stabilized difluoroborane intermediate. The method developed was expanded further for the conversion of organotrifluoroborates to the corresponding boronate esters. 2009 American Chemical Society.