628692-80-8Relevant academic research and scientific papers
11,12-Epoxyeicosatrienoic acid (11,12-EET): Structural determinants for inhibition of TNF-α-induced VCAM-1 expression
Falck,Reddy, L. Manmohan,Reddy, Y. Krishna,Bondlela, Muralidhar,Krishna, U. Murali,Ji, Yu,Sun, Jianxin,Liao, James K.
, p. 4011 - 4014 (2003)
A series of 11,12-EET analogues were synthesized and compared using a human endothelial cell based TNF-α-induced VCAM-1 expression assay. The resulting data were used to map a putative recognition/binding domain for 11,12-EET.
Compositions and Methods for the Treatment of Renal and Cardiovascular Disease
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Page/Page column 6-7, (2008/12/06)
Derivative compounds of 11-nonyloxy-undec-8(Z)-eonic acid that mimic epoxide metabolites are provided. Also provided are compositions comprising a therapeutically effective amount of the derivative compounds. The present invention further provides methods for the use of such compositions for the treatment of renal or cardiovascular disease and/or related conditions.
