628724-05-0

Basic information

• Product Name: Benzene, [[[(2E)-3-nitro-2-butenyl]oxy]methyl]-
• CAS NO: 628724-05-0
• Molecular Formula: C11H13NO3
• Molecular Weight: 207.229
• Mol File: 628724-05-0.mol

Chemical Properties

• CAS DataBase Reference: Benzene, [[[(2E)-3-nitro-2-butenyl]oxy]methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, [[[(2E)-3-nitro-2-butenyl]oxy]methyl]-(628724-05-0)
• EPA Substance Registry System: Benzene, [[[(2E)-3-nitro-2-butenyl]oxy]methyl]-(628724-05-0)

Safety Data

• Hazardous Substances Data: 628724-05-0(Hazardous Substances Data)

Upstream product

• 79-24-3 Nitroethane 
• 60656-87-3 benzyloxyacetoaldehyde 

Downstream Products

• 628724-07-2 (3S,4R)-3-Benzyloxymethyl-4-[1,3]dioxolan-2-yl-pentan-2-one 
• 628724-08-3 2-(2-benzyloxymethyl-1-methyl-3-nitro-butyl)-[1,3]dioxolane 
• 628724-06-1 3-benzyloxymethyl-2-methyl-4-nitro-pentanal 

Relevant articles and documents

Organocatalytic Michael addition, a convenient tool in total synthesis. First asymmetric synthesis of (-)-botryodiplodin

The asymmetric Michael addition of propionaldehyde to (2E)-(3-nitro-but-2-enyloxymethyl)-benzene 8, catalyzed by the chiral diamine (S,S)-N-iPr-2,2′-bipyrrolidine, afforded, with 93% ee, a precursor 9 of (-)-botryodiplodin. The nitro functionality of 9 was converted to a ketone via a Nef reaction to give, after a few steps, the enantiomerically enriched (-)-botryodiplodin.