62888-68-0Relevant academic research and scientific papers
New reduction reaction of benzylic alcohols with acid and proof of the intermolecular hydride shift mechanism
Kihara, Masaru,Andoh, Jun-Ichi,Yoshida, Chiaki
, p. 359 - 372 (2000)
The new reduction reaction of the hydroxy groups of 4-hydroxy-4-phenyl- 1,2,3,4-tetrahydroisoquinolines (1) to the corresponding alkanes (2) with mineral and Lewis acids is reported. A stereoselective intermolecular hydride shift mechanism of the reduction was proved by reaction of the deuterated derivatives (14 and 15) of 1a with 10N HCl-C2H5OH and BBr3 in CH3CN.
