62899-01-8Relevant academic research and scientific papers
Alkylation of 6-methyluracil and its derivatives
Krivonogov,Tolstikov,Murinov,Spirikhin,Fatykhov,Abdrakhmanov
, p. 301 - 306 (2007/10/03)
Alkylation of 6-methyluracil, 5-hydroxy-6-methyluracil, and 6-methyluracil-5-ammonium sulfate by allyl and propynyl bromide in DMF in the presence of K2CO3 and tetrabutylammonium bromide and the reaction products were studied.
SYNTHESIS AND ANTIVIRAL ACTIVITY OF ACYCLIC NUCLEOSIDE ANALOGUES OF 6-METHYLURACIL AND 4-ALKYLAMINO-6-METHYL-2(1H)-PYRIMIDINONES
Bhat, Sunita
, p. 683 - 690 (2007/10/02)
Reaction of 2,4-dimethoxy-6-methylpyrimidine (I) with allyl bromide or benzyl bromide afforded 1-substituted 4-methoxy-6-methyl-2(1H)-pyrimidinone intermediates III, X.Oxidation of the compound III afforded racemic cis diol VI.O-Demethylation and nucleophilic displacement of the intermediates III, VI, and X gave 1-substituted 6-methyluracils IV, VII, IX and 1-substituted 4-alkylamino-6-methyl-2(1H)-pyrimidinones V, VIII, XII in good yields.The compounds II - XII were evaluated against Ranikhet desease virus (RDV); compounds Vb, Vii, X, XIIb - XIId showed 100, 43, 44, 75, 72 and 100percent inhibition, respectively.
