62902-65-2

Upstream product

• 298-06-6 O,O-Diethyl hydrogen phosphorodithioate 
• 74939-78-9 (E)-4-oxo-4-(3-bromophenyl)-2-butenoic acid 
• 2142-63-4 1-(3-Bromophenyl)ethanone 
• 298-12-4 Glyoxilic acid 

Downstream Products

• 1229442-89-0 4-Amino-6-(3-bromophenyl)pyridazin-3(2H)-one 
• 1443124-86-4 N¹-(3-((3-(3-bromophenyl)-6-oxopyridazin-1(6H)-yl)methyl)phenyl)-N⁴,N⁴-diethylpiperidine-1,4-dicarboxamide 

Relevant academic research and scientific papers

Synthesis and Bioevaluation of 3,6-Diaryl-[1,2,4]triazolo[4,3-b] Pyridazines as Antitubulin Agents

A series of 3,6-diaryl-[1,2,4]triazolo[4,3-b]pyridazines were designed as a class of vinylogous CA-4 analogues. The easily isomerized (Z,E)-butadiene linker of vinylogous CA-4 was replaced by a rigid [1,2,4]triazolo[4,3-b]pyridazine scaffold. Twenty-one target compounds were synthesized and exhibited moderate to potent antiproliferative activity. The compound 4q with a 3-amino-4-methoxyphenyl moiety as the B-ring, comparable to CA-4 (IC50 = 0.009-0.012 μM), displayed the highly active antiproliferative activity against SGC-7901, A549, and HT-1080 cell lines with IC50 values of 0.014, 0.008, and 0.012 μM, respectively. Tubulin polymerization experiments indicated that 4q effectively inhibited tubulin polymerization, and immunostaining assay revealed that 4q significantly disrupted tubulin microtubule dynamics. Moreover, cell cycle studies revealed that compound 4q dramatically arrested cell cycle progression at G2/M phase in A549 cells. Molecular modeling studies showed that 4q could bind to the colchicine binding site on microtubules.

(3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors

New (3-oxo)pyridazin-4-ylurea derivatives having the chemcial structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of the phosphodiesterase IV (PDE4).

Process for producing antifungal oyridazinone derivatives

Compounds of formula (I): STR1 [wherein R1 and R3 represent hydrogen or halogen atoms, R2 represents a hydrogen or halogen atom or a lower alkyl or alkoxy group (provided R1, R2 and R3 are

Agricultural fungicidal compositions containing 6-(substituted phenyl)-pyridazinones and said pyridazinones

Agricultural fungicidal compositions containing as an active ingredient one or more of 6-(substitutedphenyl)-3(2H)-pyridazinone compounds, salts thereof and 6-(substituted-phenyl)-4,5-dihydro-3(2H)-pyridazinone compounds, as well as new pyridazinone compo