Mipomersen, also known as Kynamro, is a 20-mer phosphorothioate oligonucleotide with specific modifications in its chemical structure. It is an antisense oligonucleotide (ASO) designed to inhibit apolipoprotein B100 (Apo B100) transcription by binding to its mRNA sequence, leading to the silencing and elimination of the target through RNase H1 degradation. Mipomersen was approved by the US FDA in January 2013 as an adjunct to lipid-lowering medications and diet for patients with homozygous familial hypercholesterolemia (HoFH) to reduce low-density lipoprotein-cholesterol (LDL-C), apolipoprotein B (Apo B), total cholesterol (TC), and non-high-density lipoprotein-cholesterol (non-HDL-C).
629167-92-6
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Basic information
- Product Name: MipoMersen sodiuM
- Synonyms: MipoMersen sodiuM
- CAS NO:629167-92-6
- Molecular Formula: C230H305N67Na19O122P19S19
- Molecular Weight: 7594.800489
- EINECS: -0
- Product Categories: N/A
- Mol File: 629167-92-6.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: MipoMersen sodiuM(CAS DataBase Reference)
- NIST Chemistry Reference: MipoMersen sodiuM(629167-92-6)
- EPA Substance Registry System: MipoMersen sodiuM(629167-92-6)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 629167-92-6(Hazardous Substances Data)
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629167-92-6 Usage
Uses
Used in Pharmaceutical Industry:Mipomersen is used as a lipid-lowering agent for patients with homozygous familial hypercholesterolemia (HoFH) to reduce the levels of low-density lipoprotein-cholesterol (LDL-C), apolipoprotein B (Apo B), total cholesterol (TC), and non-high-density lipoprotein-cholesterol (non-HDL-C). It functions by inhibiting the transcription of apolipoprotein B100, a key protein involved in the regulation of cholesterol levels in the body.
Used in Research and Development:
Mipomersen is also used in the research and development of novel drug delivery systems and therapeutic strategies for various diseases, particularly those involving the dysregulation of cholesterol metabolism. Its antisense oligonucleotide (ASO) mechanism of action provides a valuable tool for understanding the molecular pathways involved in cholesterol regulation and the development of new treatments for related conditions.
Originator
ISIS Pharmaceuticals (United States)Check Digit Verification of cas no
The CAS Registry Mumber 629167-92-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,2,9,1,6 and 7 respectively; the second part has 2 digits, 9 and 2 respectively.Calculate Digit Verification of CAS Registry Number 629167-92:
(8*6)+(7*2)+(6*9)+(5*1)+(4*6)+(3*7)+(2*9)+(1*2)=186
186 % 10 = 6
So 629167-92-6 is a valid CAS Registry Number.
629167-92-6Upstream product
629167-92-6Downstream Products
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MipoMersen sodiuM
