62921-34-0

Basic information

• Product Name: (12Z,14E,24Z)-5,6,11,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1-oxo-1,2,7,10-tetrahydro-2,8-(epoxytetradeca[1,11,13]trieno)[1]benzofuro[4,5-g]quinazolin-21-yl acetate
• CAS NO: 62921-34-0
• Molecular Formula: C₃₈H₄₈N₂O₁₁
• Molecular Weight: 708.7945
• Mol File: 62921-34-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 847.5°C at 760 mmHg
• Flash Point: 466.3°C
• Density: 1.37g/cm³
• Vapor Pressure: 1.55E-30mmHg at 25°C
• Refractive Index: 1.623
• CAS DataBase Reference: (12Z,14E,24Z)-5,6,11,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1-oxo-1,2,7,10-tetrahydro-2,8-(epoxytetradeca[1,11,13]trieno)[1]benzofuro[4,5-g]quinazolin-21-yl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: (12Z,14E,24Z)-5,6,11,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1-oxo-1,2,7,10-tetrahydro-2,8-(epoxytetradeca[1,11,13]trieno)[1]benzofuro[4,5-g]quinazolin-21-yl acetate(62921-34-0)
• EPA Substance Registry System: (12Z,14E,24Z)-5,6,11,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1-oxo-1,2,7,10-tetrahydro-2,8-(epoxytetradeca[1,11,13]trieno)[1]benzofuro[4,5-g]quinazolin-21-yl acetate(62921-34-0)

Safety Data

• Hazardous Substances Data: 62921-34-0(Hazardous Substances Data)

Usage

General Description

The chemical compound "(12Z,14E,24Z)-5,6,11,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1-oxo-1,2,7,10-tetrahydro-2,8-(epoxytetradeca[1,11,13]trieno)[1]benzofuro[4,5-g]quinazolin-21-yl acetate" is a complex molecule with a lengthy and detailed structural formula. It contains a benzofuroquinazolinyl acetate core with a series of hydroxy and methoxy groups as well as heptamethyl and epoxytetradeca[1,11,13]trieno moieties. (12Z,14E,24Z)-5,6,11,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1-oxo-1,2,7,10-tetrahydro-2,8-(epoxytetradeca[1,11,13]trieno)[1]benzofuro[4,5-g]quinazolin-21-yl acetate presents a challenging synthesis due to its extensive structure and diverse functional groups, and it may have potential applications in the field of medicinal chemistry, biochemistry, or organic synthesis due to its unique and complex structure.

Upstream product

• 62921-32-8 3-Aminomethyl-rifamycin SV 
• 13292-22-3 3-formylrifamycin SV 
• 13292-22-3 3-formylrifamycin SV 

Downstream Products

• 62921-35-1 Chinon 4 
• 62921-38-4 (1²S,3E,5S,13E,15Z)-7t-acetoxy-1⁵,9c,11t-trihydroxy-5r-methoxy-1^2,4,6t,8c,10c,12t,16-heptamethyl-2-oxa-1(2,8)-furo[2',3':5,6]benzo[1,2-g]quinazolina-cyclohexadecaphane-3,13,15-triene-1^1,6,11-trione 

Relevant articles and documents

Preparation of some novel rifamycins by a facile intramolecular dehydration

-

3-N-substituted aminomethyl derivatives of rifamycin SV. A convenient method of synthesis, cyclization of certain derivatives, and anticellular and antiviral activities of several derivatives

A new synthesis of Mannich bases of rifamycin SV using the Borch procedure with rifaldehyde is described. This new synthesis offers two advantages over the previously published method. It provides a route to monoalkyl-aminomethylrifamycins (1e-h) and to unsubstituted aminomethylrifamycins that were not accessible by the old procedure. The new method also offers a preparative route to Mannich bases 1a and 1b which were needed in multigram quantities for biological testing. In addition, the cyclization of certain of the monoalkylaminomethylrifamycins to the novel N,15 didehydro 15 deoxo 3,15 epi[methano(alkylimino)]rifamycin SV derivatives is described. The anticellular and antiviral effects of representatives of both series of compounds against cultured mouse cells and murine oncornavirus are discussed.