62928-73-8

Upstream product

• 25834-57-5 6,9-dibromo-1,4-dioxaspiro<4.4>nonane 
• 4576-45-8 endo-dicyclopentadiene-1,8-dione bis(ethylene ketal) 
• 176-32-9 1,4-dioxaspiro[4.4]nonane 
• 4576-44-7 C₁₂H₁₂O₃ 

Downstream Products

• 14725-77-0 pentacyclo<5.3.0.0^2,5.0^3,9.0^4,8>dodecane-6,10-dione 

Relevant academic research and scientific papers

Preparation and testing of homocubyl amines as therapeutic NMDA receptor antagonists

Computational modeling demonstrates that the van-der-Waals surfaces of homocubyl amines are similar to that of the neuroprotector Memantine . Utilizing readily available precursors we report the preparation of a series of homological cubylamines, namely pentacyclo[6.3.0. 02,6.03,10.05,9]undecyl-4-amine (trishomocubyl-4-amine, 2), pentacyclo[5.3.0.02,5.0 3,9.04,8]decyl-10-amine (bishomocubyl-10-amine, 3), pentacyclo[4.3.0.02,5.03,8.04,7]nonyl-9-amine (homocubyl-9-amine, 4), and pentacyclo[4.2.0.02,5.0 3,8.04,7]octyl-1-amine (cubylamine, 5). The hydrochlorides of amines 2-5 show pronounced affinity for the (+)MK-801 channel binding site, and it seems likely that these compounds would act as very fast voltage-dependent NMDA receptor antagonists.