62928-86-3

Upstream product

• 552-85-2 4-((1R,2S)-2-amino-1-hydroxypropyl)phenol 
• 552-85-2 p-hydroxynorepherdine 
• 100-46-9 benzylamine 
• 103-49-1 dibenzylamine 
• 25070-02-4 (1RS,2RS)-2-dibenzylamino-1-(4-benzyloxy-phenyl)-propan-1-ol 
• 104-88-1 4-chlorobenzaldehyde 
• 635304-44-8 (1R, 2S)-1-[4-(benzyloxy)phenyl]-2-[((1R)-phenylethyl)amino]-1-propanol 
• 635304-65-3 (2S)-1-(4-hydroxyphenyl)-2-[((1R)-phenylethyl)amino]-1-propanone 
• 635304-39-1 (2S)-1-[4-(benzyloxy)phenyl]-2-[((1R)-phenylethyl)amino]-1-propanone methanesulfonate 
• 552-85-2 (+/-)-p-Hydroxy-norephedrin 
• 481702-60-7 tert-butyl N-[(1S,2R)-2-(4-benzyloxyphenyl)-2-hydroxy-1-methylethyl]carbamate 
• 376581-16-7 (4S,5S)-5-(4-benzyloxyphenyl)-4-methyloxazolidin-2-one 

Downstream Products

• 247073-81-0 ethyl 2-[4-(2-{[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino}ethyl)phenoxy]-2-methylpropionate 
• 247073-83-2 2-(4-{2-[(1S,2R)-2-Hydroxy-2-(4-hydroxy-phenyl)-1-methyl-ethylamino]-ethyl}-2-methyl-phenoxy)-2-methyl-propionic acid ethyl ester 
• 247073-80-9 ethyl 2-[3-chloro-4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]phenoxy]-2-methylpropionate 
• 247073-82-1 ethyl 2-[2-chloro-4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxy-phenyl)-1-methylethyl]amino]ethyl]phenoxy]-2-methyl-propionate 
• 376581-16-7 (4S,5S)-5-(4-benzyloxyphenyl)-4-methyloxazolidin-2-one 
• 481702-60-7 tert-butyl N-[(1S,2R)-2-(4-benzyloxyphenyl)-2-hydroxy-1-methylethyl]carbamate 
• 220129-47-5 Ethyl 2-[3-chloro-4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]phenoxy]acetate 
• 395-28-8 (1RS,2RS)-1-(4-hydroxy-phenyl)-2-((Ξ)-β-phenoxy-isopropylamino)-propan-1-ol 
• 395-28-8 (+/-)-1-<4-Hydroxyphenyl>-2-<1-methyl-2-phenoxyaethylamino>-propan-1-ol 
• 395-28-8 (1RS,2SR)-1-(4-hydroxy-phenyl)-2-((RS)-β-phenoxy-isopropylamino)-propan-1-ol 
• 17885-18-6 (1RS,2SR)-1-acetoxy-1-(4-acetoxy-phenyl)-2-acetylamino-propane 

Relevant academic research and scientific papers

Method for synthesizing ritodrine hydrochloride

The invention discloses a method for synthesizing ritodrine hydrochloride. The method comprises that p-chlorobenzaldehyde and pyruvic acid as substrates undergo a catalytic reaction, the product is purified to form (R)-1-(4-chlorophenyl)-1-hydroxypropane-2-one, the (R)-1-(4-chlorophenyl)-1-hydroxypropane-2-one and ammonium formate as substrates undergo a catalytic reaction, the product is purifiedto form (1R, 2S)-2-amino-1-(4-chlorophenyl)-1-propanol, the (1R, 2S)-2-amino-1-(4-chlorophenyl)-1-propanol and LiOH. H2O undergo a reaction to produce 4-((1R, 2S)-2-amino-1-hydroxypropyl)phenol and 4-((1R, 2S)-2-amino-1-hydroxypropyl)phenol and 4-(2-chloroethanol)phenol undergo a reaction to produce ritodrine hydrochloride. The method realizes a low cost, utilizes mild reaction conditions and issuitable for industrial production.

A NOVEL METHOD FOR SYNTHESIS OF OPTICALLY PURE BETA-AMINO ALCOHOLS

A method for the preparation of β-amino alcohol of formula (III) in which R1 is Ph, (substituted) Ph, R2 is C1-8 alkyl or C4-6 cyclo alkyl, R3 = R4R5CHNH2 where, R4 = H, C1-8 alkyl, C4-6 cyclo alkyl, or - COOR6 (R6=C1-C8 alkyl); R5 = (subst) aryl], the method including subjecting an α-hydroxy ketone of formula (I) in which R1 and R2 are as defined above is reacted with a chiral amine of formula R3NH2 where R3 = R4R5CH- where, R4 = H, C1-8 alkyl, C4-6 cycloalkyl, or - COOR6 (R6=C1-8 alkyl), R5 = (subst) aryl] to produce a compound of formula (II) in which R1, R2 and R3 are as defined above, followed by reduction to form the compound of formula (III).

PROCESS FOR PRODUCING OPTICALLY ACTIVE s-AMINO ALCOHOL

A process for easily producing an optically active β-amino alcohol useful as a pharmaceutical intermediate from an inexpensive, readily available starting material is provided. A readily available α-substituted ketone is reacted with an optically active amine to yield a diastereomer mixture of an optically active α-substituted aminoketone. One of the diastereomers is isolated optionally after the diastereomers are converted to salts with an acid. The optically active α-substituted aminoketone or a salt thereof thus isolated was stereoselectively reduced to yield an optically active β-substituted amino alcohol. The optically active β-substituted amino alcohol is subjected to hydrogenolysis to produce an optically active β-amino alcohol or a salt thereof.

PHENOL DERIVATIVES AND METHOD OF USE THEREOF

The present invention provides novel phenol derivatives represented by the formula: wherein the carbon atom marked with (S) represents a carbon atom in S configuration; Z represents the group represented by the formula: or the formula: wherein the carbon

Relationship between stereochemistry and the beta3-adrenoceptor agonistic activity of 4'-hydroxynorephedrine derivative as an agent for treatment of frequent urination and urinary incontinence.

This report proposes a beta(3)-adrenoceptor (AR) selective agonist, 2-[2-chloro-4-(2-([(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino)ethyl)phenoxy]acetic acid (1a), as a novel agent for treating urinary bladder dysfunction. This compound and i

Antimitotic agents. Chiral isomers of ethyl [5-amino-1,2-dihydro-3-(4- hydroxyphenyl)-2-methylpyrido[3,4-b]pyrazin-7-yl]carbamate

Metabolism studies with ethyl [5-amino-1,2-dihydro-2-methyl-3- phenylpyrido[3,4-b]pyrazin-7-yl]carbamate (1) in mice were reported previously to give a hydroxylated metabolite, which was methylated to give a methoxy derivative. The metabolite and its deri