62935-73-3Relevant academic research and scientific papers
Readily functionalizable phosphonium-tagged fluorescent coumarins for enhanced detection of conjugates by mass spectrometry
Lizzul-Jurse, Antoine,Bailly, Laetitia,Hubert-Roux, Marie,Afonso, Carlos,Renard, Pierre-Yves,Sabot, Cyrille
supporting information, p. 7777 - 7791 (2016/08/24)
Fluorescent coumarins are an important class of small-molecule organic fluorophores ubiquitous in different well-established and emerging fields of research including, among others, biochemistry and chemical biology. The present work aims at covering the poor detectability of coumarin-based conjugates by mass spectrometry while keeping important photophysical properties of the coumarin core. In this context, the synthesis of readily functionalizable phosphonium-tagged coumarin derivatives enabling a dual mass-tag and fluorescence labelling of analytes or (bio)molecules of interest through a single-step protocol, is reported. The utility of these coumarins is illustrated through the preparation of fluorogenic substrates that facilitated identification of the peptide fragment released by specific proteolytic cleavages.
Modified coumarins. 14. Synthesis of 7-hydroxy-[4,3′]dichromenyl-2, 2′-dione derivatives
Dubovik,Garazd,Khilya
, p. 434 - 443 (2007/10/03)
New derivatives of 3-(2-oxochromen-4-yl)chromen-2-one, modified analogs of natural dicoumarins, were prepared from substituted coumarin-4-acetic acids.
