62937-75-1Relevant academic research and scientific papers
An expedient synthesis of the fibril binding compound FSB via sequential Pd-catalyzed coupling reactions
Mantel, Mette Louise H.,Sobjerg, Lina S.,Huynh, Tri H. V.,Ebran, Jean-Philippe,Lindhardt, Anders T.,Nielsen, Niels C.,Skrydstrup, Troels
, p. 3570 - 3573 (2008/09/20)
(Chemical Equation Presented) The styryl benzene derivative (E,E)-1-fluoro-2,5-bis(3-hydroxycarbonyl-4-hydroxy)styrylbenzene (FSB), well-known for its binding to β-amyloid peptide fibrils, was synthesized in an efficient manner exploiting two sequential palladium(0)-catalyzed coupling reactions in a 34% overall yield. This is a substantial improvement to the previously reported synthesis of FSB in 1.1%.
