62939-85-9

Basic information

• Product Name: (-)-7α-hydroxy-6β-triphenylmethoxymethyl-cis-2-oxabicyclo<3.3.0>octan-3-one
• Synonyms: (-)-7α-hydroxy-6β-triphenylmethoxymethyl-cis-2-oxabicyclo<3.3.0>octan-3-one
• CAS NO: 62939-85-9
• Molecular Weight: 414.501
• Mol File: 62939-85-9.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: (-)-7α-hydroxy-6β-triphenylmethoxymethyl-cis-2-oxabicyclo<3.3.0>octan-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-7α-hydroxy-6β-triphenylmethoxymethyl-cis-2-oxabicyclo<3.3.0>octan-3-one(62939-85-9)
• EPA Substance Registry System: (-)-7α-hydroxy-6β-triphenylmethoxymethyl-cis-2-oxabicyclo<3.3.0>octan-3-one(62939-85-9)

Safety Data

• Hazardous Substances Data: 62939-85-9(Hazardous Substances Data)

Upstream product

• 90156-85-7 7α-formyloxy-8β-formyloxymethylene-cis-2-oxabicyclo<3.3.0>octan-3-one 
• 26054-46-6 cis-(±)-2-oxabicyclo[3.3.0]oct-6-en-3-one 
• 76-83-5 trityl chloride 
• 54423-47-1 (+/-)-(3aα,4α,5β,6aα)-5-hydroxy-4-(hydroxymethyl)hexahydro-2H-cyclopentafuran-2-one 
• 88910-97-8 (1R,4R,5R,7S)-5-Chloro-7-trityloxymethyl-bicyclo[2.2.1]heptan-2-one 
• 39746-00-4 (1S,5R,6S,7R)-7-benzoyloxy-6-hydroxymethyl-2-oxabicyclo[3.3.0]octan-3-one 
• 101208-17-7 (3aR,4S,5R,6aS)-5-(benzoyloxy)hexahydro-4-[(triphenylmethoxy)methyl]-2H-cyclopenta[b]furan-2-one 
• 88924-49-6 (1R,5R,6R,8S)-6-Chloro-8-trityloxymethyl-2-oxa-bicyclo[3.2.1]octan-3-one 
• 32233-40-2 (3aR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)hexahydro-2H-cyclopenta[b]furan-2-one 

Downstream Products

• 88910-98-9 (3aR,4S,6aS)-4-Trityloxymethyl-tetrahydro-cyclopenta[b]furan-2,5-dione 
• 1395619-06-3 (3aR,4R,5R,6aS)-5-(tert-butyldiphenylsilyloxy)-4-((E)-3-oxo-5-phenylpent-1-enyl)hexahydro-2H-cyclopenta[b]furan-2-one 
• 1395619-12-1 (3aR,4R,5R,6aS)-5-(tert-butyldiphenylsilyloxy)-4-((S,E)-3-hydroxy-5-phenylpent-1-enyl)hexahydro-2H-cyclopenta[b]furan-2-one 
• 1395618-89-9 (3aR,4S,5R,6aS)-5-(tert-butyldiphenylsilyloxy)-4-(trityloxymethyl)hexahydro-2H-cyclopenta [b] furan-2-one 
• 1395618-77-5 (3aR,4S,5R,6aS)-5-(triphenylsilyloxy)-4-(trityloxymethyl)hexahydro-2H-cyclopenta[b]furan-2-one 
• 352276-28-9 (1S,5R,6R,7R)-6-<(3S)-3-hydroxy-5-phenyl-1-pentyl>-7(R)-hydroxy-2-oxabicyclo<3.3.0>octan-3-ol 
• 38344-08-0 (5Z)-bimatoprost acid 
• 856240-62-5 (3aR,4R,5R,6aS)-hexahydro-4-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]-2H-cyclopenta[b]furan-2,5-diol 
• 41639-83-2 latanoprost acid 
• 1395619-18-7 (3aR,4R,5R,6aS)-5-(tert-butyldiphenylsilyloxy)-4-((S,E)-3-hydroxy-5-phenylpent-1-enyl)hexahydro-2H-cyclopenta[b]furan-2-ol 
• 1395618-83-3 (3aR,4S,5R,6aS)-4-(hydroxymethyl)-5-(triphenylsilyloxy)hexahydro-2H-cyclopenta[b]furan-2-one 
• 130209-82-4 latanoprost 
• 101208-17-7 (3aR,4S,5R,6aS)-5-(benzoyloxy)hexahydro-4-[(triphenylmethoxy)methyl]-2H-cyclopenta[b]furan-2-one 
• 88911-00-6 (4S,5S)-4-(2-Imidazol-1-yl-2-oxo-ethyl)-5-trityloxymethyl-cyclopent-2-enone 

Relevant articles and documents

One-pot method of preparing benzoyl the branch stands lactone (by machine translation)

The present invention discloses a one-pot method for preparing benzoyl the branch stands lactone. At the same in the reaction container, to the branch stands lactone diol as raw materials, adding solvent S1 And triphenyl methyl chloride to primary hydroxyl position of the alkylation reaction, to obtain [...] lactone solvent S [...] hydroxy derivatives1 The reaction system, benzoyl chloride to continue adding hydroxyl position of acylation reaction, and adding solvent S2 , Recrystallization, get the branch stands lactone glycol double-hydroxy derivative; adding solvent S3 And acid solution hydrolysis reaction of the primary hydroxyl group position, make the branch stands lactone crude benzoyl; adding solvent S4 Or/and S5 , Recrystallization, disposable and preparing the corresponding optically active benzoyl the branch stands lactone. The invention avoid each step reaction is repeatedly re-feeding the tedious; adequate reaction, little side reaction, high purity; after treatment is simple, high yield; and the operation is simple, time saving and high efficiency, saving the material, reducing the cost, and is suitable for industrial production. (by machine translation)

Process for the synthesis of prostaglandins and intermediates thereof

A process is disclosed for the preparation of prostaglandins of the PGF2α-series, in particular Latanoprost, Bimatoprost and Travoprost, which are active in the treatment of ocular hypertensive conditions and glaucoma. The invention also relates to novel intermediates involved in the synthesis of these prostaglandin-PGF2α derivatives.

Prostanoids: LXXXIII. Synthesis of (± )-19-carboxy-20-norprostaglandin F2α and its 15β-epimer

Starting with (±)-7α-hydroxy-6β -hydroxymethyl-2-oxa-cis-bicyclo[3.3.0]octan-3-one 15α,β -19-carboxy-20-norprostaglandins Fα were synthesized.