6294-61-7

Usage

Uses

Used in Pharmaceutical Industry:
1-Pyridin-3-yl-heptan-1-one is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs and enhance the properties of existing ones.
Used in Organic Compounds Synthesis:
As a key component, 1-Pyridin-3-yl-heptan-1-one is used in the synthesis of organic compounds, facilitating the creation of novel chemical entities with diverse applications.
Used in Fine Chemicals Production:
1-Pyridin-3-yl-heptan-1-one serves as a building block in the production of fine chemicals, contributing to the creation of high-quality specialty chemicals for various industries.
Used in Agrochemicals Industry:
In agrochemicals, 1-Pyridin-3-yl-heptan-1-one is utilized for its potential role in the development of new agrochemical products, enhancing crop protection and yield.
Used in Fragrance and Flavor Industry:
Due to its unique chemical structure, 1-Pyridin-3-yl-heptan-1-one is used in the formulation of fragrance and flavor compounds, adding novel scents and tastes to consumer products.
Used in Biological Research:
1-Pyridin-3-yl-heptan-1-one is studied for its potential biological activities and pharmacological properties, indicating its use in scientific research to explore new therapeutic avenues and understand its interactions with biological systems.

InChI:InChI=1/C12H17NO/c1-2-3-4-5-8-12(14)11-7-6-9-13-10-11/h6-7,9-10H,2-5,8H2,1H3

Upstream product

• 20260-53-1 pyridine-3-carbonyl chloride hydrochloride 
• 21369-64-2 n-hexyllithium 
• 95091-91-1 N-methoxy-N-methylpyridine-3-carboxamide 
• 100-54-9 pyridine-3-carbonitrile 
• 626-55-1 3-Bromopyridine 
• 629-08-3 heptanenitrile 

Downstream Products

• 129813-37-2 1-(2,5-Dimethoxy-3,4,6-trimethyl-phenyl)-1-pyridin-3-yl-heptan-1-ol 
• 117574-42-2 1-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-1-(pyridin-3-yl)heptane 
• 117585-86-1 3-[(Z)-1-(2,5-Dimethoxy-3,4,6-trimethyl-phenyl)-hept-1-enyl]-pyridine 
• 117574-51-3 1-(3,6-dimethoxy-2,4,5-trimethylphenyl)-1-(pyridin-3-yl)heptane 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUNDS WITH AFFINITY TO MUSCARINIC RECEPTORS

The present invention relates to heterocyclic compounds of the formula (I) wherein - the heterocycle comprises two double bonds which may be present at several positions, represented by the dashed lines ( -- ); - the heterocycle contains two heteroatoms,

Quinone derivatives, their production and use.

Quinone derivatives represented by the general formula (wherein, R1 and R2, which are the same or different, refer to a hydrogen atom, methyl or methoxymethyl group, or R1 and R2 bind together to form-CH=CH-CH=CH-; R3 is a hydrogen atom or methyl group; R? is a nitrogen-containing heterocyclic group which may be substituted; R? is a hydrogen atom, methyl group, hydroxymethyl group which may be substituted, or a carboxyl group which may be (wherein, R' is a hydrogen atom or methyl group); n is an integer from 0 through 12, m is an integer from 0 through 3, and k is an integer from 0 through 7, providing that, when m is 2 or 3, Z and k are able to vary appropri-ately in the repeating unit shown in [ ] ), and the hydro-quinone derivatives thereof, are novel compounds, possess improvement effects of metabolism of poly unsaturated fatty acids, particularly two or more of inhibition of production of fatty acid peroxides, inhibition of production of metabo-lites in 5-lipoxygenase pathway, inhibition of thromboxane A? synthetase, thromboxane A? receptor antagonism and scavenging action of active oxygen species, and of use as drugs, such as antithrombotics, anti-vascular constriction agents, anti-asthma agent, antiallergic agents, therapeutics for psoriasis, agents for improvement in heart, brain and cardiovascular systems, therapeutics for nephritis, active oxygen-eliminating agents, anticancer agents, agents for improvement of control of arachidonate cascade products, etc.

Dual Inhibitors of Thromboxane A2 Synthase and 5-Lipoxygenase with Scavenging Activity of Active Oxygen Species. Synthesis of a Novel Series of (3-Pyridylmethyl)benzoquinone Derivatives

A novel series of (3-pyridylmethyl)benzoquinone derivatives was molecular designed and synthesized for the dual purpose of inhibiting thromboxane A2 and leukotriene biosynthesis enzymes and scavenging active oxygen species (AOS).They were evaluated for inhibition of TXA2 synthase, inhibition of 5-lipoxygenase, and for their scavenging activity of AOS using the thiobarbituric acid method. 2,3,5-Trimethyl-6-(3-pyridylmethyl)-1,4-benzoquinone (24, CV-6504) was the most promising derivative since it showed efficient AOS scavenging activity (inhibition of lipid peroxidation in rat brain homogenates: IC50 = 1.8 10-6 M) as well as potent, specific, and well-balanced inhibitory effects on both enzymes (inhibitory effect on TXA2 synthase in human blood, IC50 = 3.3 10-7 M; inhibitory effect on 5-lipoxygenase in human blood, IC50 = 3.6 10-7 M).In adriamycin-induced proteinuria in a rat model, compound 24 at 10 mg/kg per day (po) suppressed proteinuria by more than 50percent.The proteinuria, however, could not be reduced by single administration of an inhibitor specific for thromboxane A2 synthase or for 5-lipoxygenase .The proteinuria was also not reduced by administration of an AOS scavenger, 2-O-octadecylascorbic acid (4, CV-3611).Triple function compounds such as compound 24 that specifically inhibit both enzymes as well as scavenge AOS possess a variety of pharmacologically beneficial effects.

Certain benzoquinones, naphthoquinones, corresponding hydroquinones which exhibit thromboxane A2 synthetase inhibition or receptor antagonism and the like

Quinone derivatives represented by the general formula STR1 (wherein, R1 and R2, the same or different, refer to a hydrogen atom, methyl or methoxymethyl group, or R1 and R2 bind together to form --CH=CH--CH=CH--; R3 is a hydrogen atom or methyl group; R4 is a nitrogen-containing heterocyclic group which may be substituted; R5 is a hydrogen atom, methyl group, hydroxymethyl group which may be substituted, or a carboxyl group which may be esterified or amidated; Z is STR2 (wherein, R' is hydrogen atom or methyl group); n is an integer from 0 through 12, m is an integer from 0 through 3, and k is an integer from 0 through 7, providing that, when m is 2 or 3, Z and k are able to vary appropriately in the repeating unit shown in [ ]), and the hydroquinone derivatives thereof, are novel compounds, possess improvement effects of metabolism of polyunsaturated fatty acids, particularly two or more of inhibition of production of fatty acid peroxides, inhibition of production of metabolites in 5-lipoxygenase pathway, inhibition of thromboxane A2 synthetase, thromboxane A2 receptor antagonism and scavenging action of active oxygen species, and of use as drugs, such as antithrombotics, anti-vascular constriction agents, anti-asthma agent, antiallergic agents, therapeutics for psoriasis, agents for improvement in heart, brain and cardiovascular systems, therapeutics for nephritis, active oxygen-eliminating agents, anticancer agents, agents for improvement of control of arachidonate cascade products, etc.