6294-93-5

Basic information

• Product Name: 2-CHLORO-5-HYDROXYBENZOTRIFLUORIDE
• Synonyms: p-chloro-m-trifluoromethyl-pheno;p-chloro-m-trifluoromethylphenol;2-CHLORO-5-HYDROXYBENZOTRIFLUORIDE;4-CHLORO-3-(TRIFLUOROMETHYL)PHENOL;3-(TRIFLUOROMETHYL)-4-CHLOROPHENOL;2-Chloro-5-hydroxybenzotrifluoride 98%;2-Chloro-5-hydroxybenzotrifluoride98%;α,α,α-trifluoro-4-chloro-M-cresol
• CAS NO: 6294-93-5
• Molecular Formula: C₇H₄ClF₃O
• Molecular Weight: 196.55
• Product Categories: Phenol&Thiophenol&Mercaptan;NULL
• Mol File: 6294-93-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 44-46°C
• Boiling Point: 120-122°C 27mm
• Flash Point: 120-122°C/27mm
• Appearance: /
• Density: 1.4690 (estimate)
• Vapor Pressure: 0.0398mmHg at 25°C
• Refractive Index: 1.482
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 8.52±0.18(Predicted)
• BRN: 2261083
• CAS DataBase Reference: 2-CHLORO-5-HYDROXYBENZOTRIFLUORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-5-HYDROXYBENZOTRIFLUORIDE(6294-93-5)
• EPA Substance Registry System: 2-CHLORO-5-HYDROXYBENZOTRIFLUORIDE(6294-93-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-36-34-21/22
• Safety Statements: 26-36/37/39-45
• RIDADR: 3261
• RTECS: SK6040000
• HazardClass: IRRITANT
• PackingGroup: Ⅲ
• Hazardous Substances Data: 6294-93-5(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow crystalline

InChI:InChI=1/C7H4ClF3O/c8-6-2-1-4(12)3-5(6)7(9,10)11/h1-3,12H

Upstream product

• 89634-75-3 1-chloro-4-fluoro-2-(trifluoromethyl)benzene 
• 777-37-7 4-chloro-3-(trifluoromethyl)nitrobenzene 
• 320-51-4 4-chloro-3-trifluoromethyl-aniline 

Downstream Products

• 434-47-9 2,4-dichloro-3-trifluoromethyl-phenol 
• 370-10-5 (4-chloro-3-trifluoromethyl-phenyl)-(4-nitro-benzyl)-ether 
• 23794-70-9 (4-Trifluoromethyl-phenyl)-carbamic acid 4-chloro-3-trifluoromethyl-phenyl ester 
• 516481-95-1 4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}benzaldehyde 
• 951136-78-0 C₁₄H₇BrClF₃O₂ 
• 384-88-3 2,4-dichloro-3-trifluoromethyl-anisole 
• 579-47-5 (2,4-dichloro-3-trifluoromethyl-phenyl)-(4-nitro-benzyl)-ether 
• 361377-27-7 4-[4-chloro-3-(trifluoromethyl)phenoxy]-5-fluoro-6-[4-fluoro-3-(trifluoromethyl)phenoxy]pyrimidine 
• 98-17-9 3-Trifluoromethylphenol 
• 1203898-21-8 2-bromo-4-chloro-5-(trifluoromethyl)phenol 
• 1192021-57-0 2-amino-6-chloro-3-hydroxybenzotrifluoride 
• 1282541-11-0 N-[3-chloro-6-hydroxy-2-trifluoromethylphenyl]isonicotinamide 
• 1629184-46-8 4-chloro-5-fluoro-2-phenylnaphthalen-1-ol 
• 20501-40-0 2,4-Dichloro-3-(4-chloro-3-trifluoromethyl-phenoxy)-6-nitro-phenylamine 

Relevant articles and documents

9-AZABICYCLO [3 . 3 . 1] NONANE DERIVATIVES AS MONOAMINE REUPTAKE INHIBITORS

The present invention relates to a 9-azabicyclo[3.3.1]nonane derivative of formula (I), wherein R1 is H or C1-5alkyl; X is O or NR2, wherein R2 is H, C1-5alkyl or C2-5acyl and Ar is C6-10aryl or a 5-10 membered heteroaryl ring system, both being optionally substituted with one to three of R3-R5 independently selected from halogen, C1-5alkyl, C1-5alkoxy, C3-6cycloalkyl, C2-5alkenyl, C2-5alkynyl, CN, NO2, hydroxy, phenyl, phenoxy and phenylC1-2alkoxy, wherein said C1-5alkyl and C1-5alkoxy are optionally substituted with one to three halogens and wherein said phenyl, phenoxy and phenylC1-2alkoxy are optionally substituted with one to three substituents independently selected from halogen and methyl or two of R3-R5 at adjacent positions together form a methylenedioxy or propylene unit, with the proviso that the compounds exo-9-methyl-3-phenoxy-9-azabicyclo[3.3.1]nonane and N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-1H indazole-5-amine are excluded, or a pharmaceutically acceptable salt or solvate thereof. The invention also relates to pharmaceutical compositions comprising said 9-azabicyclo[3.3.1]nonane derivatives and to their use in therapy.

3-chloro-4-fluoro-5-nitrobenzotrifluoride

Chloro-aromatic compounds of the formula STR1 wherein R is CF3, OCF3, OC2 F5, CN, NCO, or COCl, m is 0, 1 or 2; n is 0, 1 or 2; q is 1 or 2; q+m+n is less than 6; and when q is 1, m is 2; are prepared by the vapor phase chloro-denitration reaction of a chlorinating agent with a nitro-aromatic compound of the formula STR2 where R, m, n and q are as defined above.