629625-96-3

Usage

Molecular class

Piperazine compounds

Common use

Intermediate in the synthesis of various pharmaceuticals and agrochemicals

Potential applications

Medicinal chemistry and drug discovery

Use as a building block

Production of various organic compounds

Safety

Handle with care and follow appropriate safety protocols in a laboratory setting.

Upstream product

• 31166-44-6 phenylmethyl 1-piperazinecarboxylate 
• 6226-25-1 2,2,2-trifluoroethyl trifluoromethanesulphonate 
• 31970-04-4 1-carboxybenzyl-3-pyrrolidine 
• 127747-10-8 N-(benzyloxycarbonyl)iminodiacetaldehyde 
• 373-88-6 2,2,2-trifluroethylamine hydrochloride 

Downstream Products

• 13349-90-1 1-(2,2,2-trifluoroethyl)piperazine 

Relevant academic research and scientific papers

An Improved Stereocontrolled Access Route to Piperidine or Azepane β-Amino Esters and Azabicyclic β- and γ-Lactams; Synthesis of Novel Functionalized Azaheterocyles

An improved, efficient synthesis of some functionalized saturated azaheterocycles has been accomplished by controlled functionalization of various readily available cyclic compounds containing ring C=C bond. The stereocontrolled synthetic concept was based on the oxidative ring cleavage of various unsaturated scaffolds across ozonolysis followed by ring closing with double reductive amination with primary alkylamines or fluorinated alkylamines. The protocol provided versatile azaheterocyclic derivatives with a piperidine or azepane framework.

NOVEL PHYSIOLGICALLY ACTIVE SUBSTANCES

The present invention relates to a compound represented by the formula (I): (wherein, R3, R6, R7 and R21 are the same as or different from one another and each represents a hydroxyl group etc.), a pharmacologically acceptable salt thereof or a hydrate of them. The compound (I) of the present invention suppresses angiogenesis, in particular, suppresses VEGF production in a hypoxic condition and is useful as a therapeutic agent for treating solid cancer.