62968-33-6Relevant academic research and scientific papers
INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE I FOR THE TREATMENT OF DISEASE
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Paragraph 0313, (2021/09/04)
Disclosed herein are compounds which inhibit RIPK1, pharmaceutical compositions, and methods of treatment of RIPK1-mediated diseases, such as neurodegenerative disorders, inflammatory disorders, and cancer.
Reaction of N-Substituted Cyclic Amines with 2,4-Dichloroquinazoline, 2,4-Dichloropyrimidine, and its 5-Methyl Derivative
Yoshida, Kenji,Taguchi, Masahiro
, p. 919 - 922 (2007/10/02)
The reaction of N-substituted cyclic amines with 2,4-dichloroquinazoline 2 and 2,4-dichloro-5-methyl-pyrimidine 3b afforded 2-amino-4-chloroquinazolines and 2-amino-4-chloro-5-methylpyrimidines, respectively.However, the reaction of these amines with 2,4-dichloropyrimidine 3a afforded not only 2-amino-4-chloropyrimidines but also the isomeric 4-amino-2-chloropyrimidines.The regioselectivity of these reactions was considered to be determined by the steric nature of substrates 2, 3a and 3b.
