62980-03-4

Basic information

• Product Name: 3-TRIFLUOROMETHYL-BENZAMIDINE HCL
• Synonyms: 3-trifluoromethyl-benzamide hydrochloride;3-(TrifluoroMethyl)benziMidaMide hydrochloride;3-TRIFLUOROMETHYL-BENZAMIDINE HCL;3-TRIFLUOROMETHYL-BENZAMIDINE HYDROCHLORIDE;3-Trifluoromethyl-Benzamidine Hc
• CAS NO: 62980-03-4
• Molecular Formula: C₈H₇F₃N₂*ClH
• Molecular Weight: 224.61
• Product Categories: pharmacetical
• Mol File: 62980-03-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 221.7°C at 760 mmHg
• Flash Point: 87.9°C
• Appearance: /
• Vapor Pressure: 0.106mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 3-TRIFLUOROMETHYL-BENZAMIDINE HCL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-TRIFLUOROMETHYL-BENZAMIDINE HCL(62980-03-4)
• EPA Substance Registry System: 3-TRIFLUOROMETHYL-BENZAMIDINE HCL(62980-03-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 62980-03-4(Hazardous Substances Data)

Usage

General Description

3-Trifluoromethyl-benzamidine HCl is a chemical compound with the molecular formula C8H8F3N3O and a molar mass of 205.16 g/mol. It is a white to off-white crystalline powder that is soluble in water and methanol. 3-TRIFLUOROMETHYL-BENZAMIDINE HCL is often used as a reagent in organic synthesis and pharmaceutical research due to its ability to act as a potent inhibitor of serine proteases. It is also commonly utilized in the development of novel drug candidates and biochemical assays, particularly in the study of protein structure and function. Additionally, 3-Trifluoromethyl-benzamidine HCl has been investigated for its potential applications in the treatment of various diseases and medical conditions, owing to its unique molecular properties and biological activity.

InChI:InChI=1/C8H7F3N2.ClH/c9-8(10,11)6-3-1-2-5(4-6)7(12)13;/h1-4H,(H3,12,13);1H

Upstream product

• 56108-09-9 methyl 3-(trifluoromethyl)benzimidate hydrochloride 
• 368-77-4 3-trifluoromethylbenzonitrile 

Downstream Products

• 1613637-85-6 2,4-bis(3-(trifluoromethyl)phenyl)-1,3,5-triazine 
• 1613637-92-5 2-(4-nitrophenyl)-4-(3-(trifluoromethyl)phenyl)-1,3,5-triazine 
• 58884-90-5 3,5-bis(3-(trifluoromethyl)phenyl)-4H-1,2,4-triazole 
• 1332501-22-0 5-(5-chlorothiophen-2-yl)-4-(2-fluorobenzyl)-2-({5-[3-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 1332501-14-0 5-(4-chlorophenyl)-4-cyclopropyl-2-({5-[3-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 851507-91-0 4-cyclopropyl-2-(3-trifluoromethyl-phenyl)-pyrimidine-5-carboxylic acid ethyl ester 
• 1158984-55-4 ethyl-5-(2-(3-trifluoromethylphenyl)-pyrimidin-4-yl)-thiophene-2-carboxylate 
• 1116454-23-9 4-Cyclopropyl-6-methyl-2-(3-trifluoromethyl-phenyl)-pyrimidine-5-carboxylic acid ethyl ester 
• 1116454-20-6 4,6-dimethyl-2-(3-trifluoromethyl-phenyl)-pyrimidine-5-carboxylic acid ethyl ester 
• 69886-40-4 3-(Trifluoromethyl)-N-(3-phenyl-1,2,4-oxadiazol-5-yl)benzamidine 

Relevant articles and documents

Preparation of Triazolopyrimidines as Potential Antiasthma Agents

With the use of the human basophil histamine release assay, 5-aryl-2-aminotriazolopyrimidines were found to be active as mediator release inhibitors.These compounds were prepared by reacting arylamidines with sodium ethyl formylacetate or with ethyl propiolate to give pyrimidinones.Treatment with phosphorus oxychloride gave a chloropyrimidine, which was converted to a hydrazinopyrimidine with hydrazine.Cyclization, using cyanogen bromide, gave the triazolopyrimidines, after a Dimroth rearrangement.Following a structure-activity evaluation, the5--2-amino (8-10), 5-(3-bromophenyl)-2-amino (8-13), 5--2-amino (8-11), and 5-(4-pyridinyl)-2-amino (6-7) compounds were found to have the best activity.They were chosen for further pharmacological and toxicological study.