62980-03-4

Usage

Uses

Used in Pharmaceutical Research:
3-Trifluoromethyl-benzamidine HCl is used as a reagent for its ability to inhibit serine proteases, which is crucial in the study of protein structure and function, as well as in the development of biochemical assays.
Used in Organic Synthesis:
In the field of organic synthesis, 3-Trifluoromethyl-benzamidine HCl is utilized as a reagent due to its unique molecular properties, facilitating the creation of new compounds and contributing to the advancement of chemical research.
Used in Drug Development:
3-Trifluoromethyl-benzamidine HCl is employed as a key component in the development of novel drug candidates, leveraging its biological activity and potential therapeutic applications.
Used in Disease Treatment Research:
3-Trifluoromethyl-benzamidine HCl is investigated for its potential applications in the treatment of various diseases and medical conditions, given its unique molecular properties and biological activity, which may offer new avenues for therapeutic intervention.

InChI:InChI=1/C8H7F3N2.ClH/c9-8(10,11)6-3-1-2-5(4-6)7(12)13;/h1-4H,(H3,12,13);1H

Upstream product

• 368-77-4 3-trifluoromethylbenzonitrile 
• 56108-09-9 methyl 3-(trifluoromethyl)benzimidate hydrochloride 

Downstream Products

• 58884-90-5 3,5-bis(3-(trifluoromethyl)phenyl)-4H-1,2,4-triazole 
• 1613637-85-6 2,4-bis(3-(trifluoromethyl)phenyl)-1,3,5-triazine 
• 1613637-92-5 2-(4-nitrophenyl)-4-(3-(trifluoromethyl)phenyl)-1,3,5-triazine 
• 1332501-22-0 5-(5-chlorothiophen-2-yl)-4-(2-fluorobenzyl)-2-({5-[3-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 1332501-14-0 5-(4-chlorophenyl)-4-cyclopropyl-2-({5-[3-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 851507-91-0 4-cyclopropyl-2-(3-trifluoromethyl-phenyl)-pyrimidine-5-carboxylic acid ethyl ester 
• 1158984-55-4 ethyl-5-(2-(3-trifluoromethylphenyl)-pyrimidin-4-yl)-thiophene-2-carboxylate 
• 1116454-23-9 4-Cyclopropyl-6-methyl-2-(3-trifluoromethyl-phenyl)-pyrimidine-5-carboxylic acid ethyl ester 
• 1116454-20-6 4,6-dimethyl-2-(3-trifluoromethyl-phenyl)-pyrimidine-5-carboxylic acid ethyl ester 
• 69886-40-4 3-(Trifluoromethyl)-N-(3-phenyl-1,2,4-oxadiazol-5-yl)benzamidine 

Relevant academic research and scientific papers

Preparation of Triazolopyrimidines as Potential Antiasthma Agents

With the use of the human basophil histamine release assay, 5-aryl-2-aminotriazolopyrimidines were found to be active as mediator release inhibitors.These compounds were prepared by reacting arylamidines with sodium ethyl formylacetate or with ethyl propiolate to give pyrimidinones.Treatment with phosphorus oxychloride gave a chloropyrimidine, which was converted to a hydrazinopyrimidine with hydrazine.Cyclization, using cyanogen bromide, gave the triazolopyrimidines, after a Dimroth rearrangement.Following a structure-activity evaluation, the5--2-amino (8-10), 5-(3-bromophenyl)-2-amino (8-13), 5--2-amino (8-11), and 5-(4-pyridinyl)-2-amino (6-7) compounds were found to have the best activity.They were chosen for further pharmacological and toxicological study.

Method for the control of undesired plant species using imidazo-as-triazinones and triazine-thiones

This disclosure describes herbicidal methods for the pre- and postemergence control of undesired mono- and dicotyledonous plants using substituted imidazo[1,5-d]-as-triazin-4(3H)-ones and substituted imidazo[1,5-d]-as-triazine-4(3H)-thiones.