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62989-90-6

62989-90-6

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62989-90-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 62989-90-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,2,9,8 and 9 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 62989-90:
(7*6)+(6*2)+(5*9)+(4*8)+(3*9)+(2*9)+(1*0)=176
176 % 10 = 6
So 62989-90-6 is a valid CAS Registry Number.
InChI:InChI=1/C16H22O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-12,14-15,18H,2-3,5,9-10H2,1H3/b6-4+,8-7+/t11-,12+,14+,15+/m0/s1

62989-90-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name (1S,2E,7S,10E,12R,13R)-12-hydroxy-7-methyl-8-oxabicyclo[11.3.0]hexadeca-2,10-diene-9,15-dione

1.2 Other means of identification

Product number -
Other names 4H-Cyclopent(f)oxacyclotridecin-4,13(1H)-dione,6,7,8,9,11a,12,14,14a-octahydro-1-hydroxy-6-methyl-,(1R-(1R*,2E,6S*,10E,11aS*,14aR*))

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:62989-90-6 SDS

62989-90-6Relevant articles and documents

Synthesis and activity of brefeldin A analogs as inducers of cancer cell differentiation and apoptosis

Zhu, Ji-Wen,Hori, Hitoshi,Nojiri, Hisao,Tsukuda, Takahiko,Taira, Zenei

, p. 139 - 144 (1997)

We designed and synthesized several brefeldin A (BFA) analogs. These compounds were evaluated for the ability to induce differentiation and apoptosis in human colonic carcinoma cell line HCT116. Diacetyl BFA (2a), 4-acetyl BFA (2b), 7-acetyl BFA (2c), and 10,11-epoxy BFA (3b) were active but tetrahydro BFA (3a) and other analogs could not induce the malignant cells to differentiate. The results suggested that the moiety from 1- to 4-position in BFA as well as its conformational rigidity is essential for its biological activity.

Oxidation of brefeldin A

Proksa,Uhrin,Adamcova,Fuska

, p. 582 - 584 (2007/10/02)

Oxidation of the macrolide antibiotic brefeldin A with pyridinium chlorochromate adsorbed on alumina afforded [6S, 10E, 11aS, 14E]-6-methyl-2,3,6,7,8,9,11a,12-octahydro-4 H-cyclopent[f]oxacyclotridecin-1,4,13-trione together with 13-oxobrefeldin. These compounds showed higher cytotoxic activity on P388 leukemia cells than brefeldin A, brefeldin A-1,13-diacetate, brefeldin A-13-acetate, tetrahydrobrefeldin or tetrahydrobrefeldin-1,13-dione. 13-Oxobrefeldin exceeded brefeldin A in antifungal activity on Candida albicans.

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