62995-74-8

Upstream product

• 420-04-2 CYANAMID 
• 100-09-4 4-methoxybenzoic acid 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 13939-06-5 molybdenum hexacarbonyl 
• 696-62-8 para-iodoanisole 
• 201230-82-2 carbon monoxide 
• 19981-17-0 sodium cyanamide 

Downstream Products

• 23275-52-7 5-(4-methoxy-phenyl)-[1,2,4]oxadiazol-3-ylamine 
• 717896-85-0 6,7-dimethoxy-2-(4-methoxyphenylcarboxamido)-3,4-dihydroquinazolin-4-one 
• 810632-39-4 2-(4-methoxyphenylcarboxamido)-4-methylquinazoline 
• 77478-79-6 2-(4-methoxyphenylcarboxamido)-3,4-dihydroquinazolin-4-one 
• 717893-44-2 2-(4-methoxyphenylcarboxamido)-4-phenylquinazoline 
• 1030830-52-4 6-(4-methoxyphenylcarboxamido)-1,3,4,8,9,9a-hexahydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione 
• 51884-02-7 N-carbamoyl-4-methoxybenzamide 

Relevant academic research and scientific papers

Ultrasound-Assisted Synthesis of N -Acylcyanamides and N -Acyl-Substituted Imidazolones from Carboxylic Acids by Using Trichloroisocyanuric Acid/Triphenylphosphine

A convenient ultrasound-assisted one-pot synthesis of N -acylcyanamides starting from readily available carboxylic acids and sodium cyanamide has been developed. Upon activation in the presence of trichloroisocyanuric acid (TCCA) and triphenylphosphine, a range of carboxylic acids was converted into N -acylcyanamides in good to excellent yields within 10 minutes at room temperature without base. Remarkably, N -acyl-substituted imidazolones were readily accessible through guanylation-cyclization of the in situ generated N -acylcyanamides.

COMPOSITIONS AND METHODS COMPRISING SUBSTITUTED 2-AMINOIMIDAZOLES

The present invention presents 2-(acylamino)imidazoles with therapeutic activity, including selective activity against cancer cells, and compositions comprising them. Methods of using and preparing the 2-(acylamino)imidazoles are also presented.

Palladium-catalyzed carbonylative synthesis of N-cyanobenzamides from aryl iodides/bromides and cyanamide

A novel and convenient protocol for the synthesis of N-cyanobenzamides starting from readily available aryl halides and cyanamide via palladium-catalyzed aminocarbonylation has been developed. The protocol utilizes Mo(CO)6 as the CO source or CO(gas) and affords the desired N-cyanobenzamides in moderate to good yields.

Novel two-step, one-pot synthesis of primary acylureas

A new procedure for the synthesis of primary acylureas from cyanamide and a variety of carboxylic acids is described. Under mild reaction conditions, the products were obtained in good yield from commercially available starting materials.