630-20-6

Basic information

• Product Name: 1,1,1,2-Tetrach loroethane
• Synonyms: (Chloromethyl)trichloromethane;1,1,1,2-Tetrachloroethane;F 130a;HCC 130a
• CAS NO: 630-20-6
• Molecular Formula: C₂H₂Cl₄
• Molecular Weight: 167.84
• EINECS: 211-135-1
• Mol File: 630-20-6.mol
• Article Data: 8

Chemical Properties

• Melting Point: -70.2 °C
• Boiling Point: 132.4 °C at 760 mmHg
• Flash Point: 35.5 °C
• Appearance: colourless liquid
• Density: 1.566 g/cm³
• CAS DataBase Reference: 1,1,1,2-Tetrach loroethane(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1,1,2-Tetrach loroethane(630-20-6)
• EPA Substance Registry System: 1,1,1,2-Tetrach loroethane(630-20-6)

Safety Data

• Hazard Codes: Xn:
• Statements: R22;R40;R41:
• Safety Statements: A skin and severe eye irritant. Questionable carcinogen with experimental carcinogenic data. Incompatible with dinitrogen tetrao
• Hazardous Substances Data: 630-20-6(Hazardous Substances Data)

Usage

General Description

1,1,1,2-Tetrachloroethane, also known as perchloroethane, is a colorless and highly toxic chemical compound. It is primarily used as a solvent and as an intermediate in the production of other chemicals. It has also been used as a dry cleaning solvent and in the production of rubber and adhesives. However, due to its toxicity and environmental concerns, its use has been greatly restricted. Exposure to 1,1,1,2-Tetrachloroethane can cause a range of health issues including respiratory problems, liver and kidney damage, and nervous system disorders. It is also a known carcinogen, and prolonged or high-level exposure should be avoided.

Synthetic route

2,2,2-Trichloroethyl chloroformate (17341-93-4) → 1,1,1,2-tetrachoroethane (630-20-6) + bis(2,2,2-trichloroethyl) carbonate (5634-37-7)

Conditions	Yield
With hexabutylguanidinium chloride at 100℃; for 168h;	A 1% B 99%

1,1,1-trichloroethane (71-55-6) → 1,1,1,2-tetrachoroethane (630-20-6) + 1,1-Dichloroethylene (75-35-4) + pentachloroethane (76-01-7)

Conditions	Yield
With chlorine at 25℃; Irradiation;	A 92.5% B 2.4% C 5.1%
With chlorine at 25℃; Irradiation;	A 89.9% B 4.7% C 5.3%

1,1,1-trichloroethane (71-55-6) → 1,1,1,2-tetrachoroethane (630-20-6) + 1,1-Dichloroethylene (75-35-4)

Conditions	Yield
With chlorine at 200℃; Mechanism; Irradiation; other temperature; other laser; other Cl2 flow rate; other ratio educt/Cl2;	A 61.3% B 25.9%
With chlorine at 200℃; Irradiation;	A 61.3% B 25.9%

diethyl ether (60-29-7) + hexachloroethane (67-72-1) + ethylmagnesium bromide (925-90-6) → 1,1,2,2-tetrachloroethylene (127-18-4) + 1,1,1,2-tetrachoroethane (630-20-6) + pentachloroethane (76-01-7) + 1,1,2,2-tetrachloroethane (79-34-5)

diethyl ether (60-29-7) + hexachloroethane (67-72-1) + phenylmagnesium bromide → 1,1,2,2-tetrachloroethylene (127-18-4) + 1,1,1,2-tetrachoroethane (630-20-6) + pentachloroethane (76-01-7) + 1,1,2,2-tetrachloroethane (79-34-5)

chloroethane (75-00-3) → 1,1,1,2-tetrachoroethane (630-20-6)

Conditions	Yield
durch Chlorierung;

1,1,1-trichloroethane (71-55-6) → 1,1,1,2-tetrachoroethane (630-20-6)

Conditions	Yield
durch Chlorierung im Sonnenlicht;

1,1,1-trichloroethane (71-55-6) → 1,1,1,2-tetrachoroethane (630-20-6) + pentachloroethane (76-01-7) + hexachloroethane (67-72-1)

Conditions	Yield
Chlorierung im Sonnenlicht;

1,1-Dichloroethylene (75-35-4) → 1,1,1,2-tetrachoroethane (630-20-6)

Conditions	Yield
With chlorine at 25 - 40℃;
With chlorine; iron at 20 - 30℃;
With nitrosylchloride at 25℃;
With chlorine; iron(III) chloride

1,1-Dichloroethylene (75-35-4) → 1,1,1,2-tetrachoroethane (630-20-6) + 1,1-dichloro-2-nitro ethylene (6061-04-7)

Conditions	Yield
With nitrosylchloride at 25℃;

bis (2-chloroethyl) sulphide (505-60-2) → 1,1,1,2-tetrachoroethane (630-20-6)

Conditions	Yield
With chlorine at 25℃; und Zersetzen des Reaktionsprodukts in der Waerme unter vermindertem Druck;

1,1-diiodo-ethene (57678-85-0) → 1,1,1,2-tetrachoroethane (630-20-6)

Conditions	Yield
With tetrachloromethane; chlorine im Sonnenlicht;

Trichloroethylene (79-01-6) → 1,1,1,2-tetrachoroethane (630-20-6)

Conditions	Yield
With hydrogenchloride; aluminium trichloride
With hydrogenchloride; iron(III) chloride
With hydrogenchloride; aluminium trichloride at 30 - 40℃;
With pumice stone at 700℃;
With hydrogenchloride; chromium(III) oxide In gas at 249.9℃; Product distribution; Thermodynamic data; various temp.; ΔRH0; ΔRG0;

Trichloroethylene (79-01-6) → 1,1,2,2-tetrachloroethylene (127-18-4) + 1,1,2,4,4-pentachloro-1,3-butadiene (21400-41-9) + 1,1,1,2-tetrachoroethane (630-20-6) + 1,1,2,2-tetrachloroethane (79-34-5)

Conditions	Yield
at 200 - 250℃; under 934095 Torr; Produkt5:Pentachloraethan.Pyrolysis;

trichloroethoxycarbonyl chloride → 1,1,1,2-tetrachoroethane (630-20-6)

Conditions	Yield
With aluminium trichloride

1,2-dichloro-ethane (107-06-2) → 1,1,1,2-tetrachoroethane (630-20-6)

Conditions	Yield
durch Chlorieren;

diethyl ether (60-29-7) + hexachloroethane (67-72-1) + para-methylphenylmagnesium bromide (4294-57-9) → 1,1,2,2-tetrachloroethylene (127-18-4) + 1,1,1,2-tetrachoroethane (630-20-6) + pentachloroethane (76-01-7) + 1,1,2,2-tetrachloroethane (79-34-5)

diethyl ether (60-29-7) + hexachloroethane (67-72-1) + 1-naphthylmagnesiumbromide (703-55-9) → 1,1,2,2-tetrachloroethylene (127-18-4) + 1,1,1,2-tetrachoroethane (630-20-6) + pentachloroethane (76-01-7) + 1,1,2,2-tetrachloroethane (79-34-5)

acetylene (74-86-2) → trans-1,2-dichloroethylene (156-60-5) + 1,1,1,2-tetrachoroethane (630-20-6)

Conditions	Yield
With chlorine; pyrographite at 40℃;
With chlorine; copper dichloride at 200 - 240℃;

1,1,2,2-tetrachloroethane (79-34-5) → 1,1,1,2-tetrachoroethane (630-20-6)

Conditions	Yield
With aluminium trichloride at 110℃;
With water; calcium chloride

1,1,2-trichloroethane (79-00-5) → 1,1,1,2-tetrachoroethane (630-20-6) + 1,2,2,3,4-pentachlorobutane (2431-52-9)

Conditions	Yield
With chlorine Mechanism; Irradiation; var. temperature, concns. of Cl2, O2, laser fluence;

1,1,2-trichloroethane (79-00-5) → 1,1,1,2-tetrachoroethane (630-20-6) + 1,1,2,2-tetrachloroethane (79-34-5)

Conditions	Yield
With chlorine; 1,2-dichloro-benzene at 20℃; Product distribution; Kinetics; Mechanism; Irradiation; presence of CCl4;
With chlorine In 1,2-dichloro-benzene at -20 - 80℃; Product distribution; Mechanism; Ratio of products and rate constants; different concentrations of o-dichlorobenzene;

1,2-dichloro-1,1-difluoroethane (1649-08-7) → 1,1,1,2-tetrachoroethane (630-20-6)

Conditions	Yield
With hydrogenchloride; chromium(III) oxide In gas at 249.9℃; Thermodynamic data; various temp.; ΔRH0; ΔRG0;

aluminium trichloride (7446-70-0) + 1,1,2,2-tetrachloroethane (79-34-5) → 1,1,1,2-tetrachoroethane (630-20-6)

Conditions	Yield
at 110℃;

hydrogenchloride (7647-01-0) + aluminium trichloride (7446-70-0) + Trichloroethylene (79-01-6) → 1,1,1,2-tetrachoroethane (630-20-6)

Conditions	Yield
at 30 - 40℃;

(E)-1,2-diiodoethene (590-27-2) + chlorine (7782-50-5) → 1,1,1,2-tetrachoroethane (630-20-6)

hydrogenchloride (7647-01-0) + Trichloroethylene (79-01-6) + iron(III) chloride (7705-08-0) → 1,1,1,2-tetrachoroethane (630-20-6)

Conditions	Yield
im Dunkeln;

CH2ClCHCl2 → 1,1,1,2-tetrachoroethane (630-20-6)

Conditions	Yield
durch Chlorieren;

tris-<2,2,2-trichloro-ethyl>-phosphite → 1,1,1,2-tetrachoroethane (630-20-6)

Conditions	Yield
With diethyl ether; chlorine at 150℃;

1,1,1,2-tetrachoroethane (630-20-6) + Diethyl allylphosphonate (1067-87-4) → (2,4,4,5-Tetrachloro-pentyl)-phosphonic acid diethyl ester

Conditions	Yield
With 2-hydroxy-2-phenylacetophenone; iron(III) chloride In acetonitrile at 130℃;	25%

diazomethane (186581-53-3, 908094-01-9) + 1,1,1,2-tetrachoroethane (630-20-6) + 6-acetyl-2,3-diacetoxyphenol (27865-58-3) → 1-(3,4-diacetoxy-2-methoxy-phenyl)-ethanone + 1-(2,4-diacetoxy-3-methoxy-phenyl)-ethanone (860741-89-5)

diazomethane (186581-53-3, 908094-01-9) + 1,1,1,2-tetrachoroethane (630-20-6) + 3-acetoxy-1-hydroxy-anthraquinone (93395-14-3) → 1-methoxy-3-acetoxyanthraquinone (75299-66-0)

diazomethane (186581-53-3, 908094-01-9) + 1,1,1,2-tetrachoroethane (630-20-6) + 1-hydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yl benzoate (75697-69-7) → 2-benzoyloxy-1-methoxy-anthraquinone + 1-benzoyloxy-2-methoxy-anthraquinone (96087-89-7)

diazomethane (186581-53-3, 908094-01-9) + 1,1,1,2-tetrachoroethane (630-20-6) + 2-benzoyloxy-1,7-dihydroxy-anthraquinone → 2-benzoyloxy-1,7-dimethoxy-anthraquinone + 1-benzoyloxy-2,7-dimethoxy-anthraquinone

phthalic anhydride (85-44-9) + 1,1,1,2-tetrachoroethane (630-20-6) + (3,7-dimethyl-[1]naphthyl)-methyl ether → 2-(4-methoxy-2,6-dimethyl-[1]naphthoyl)-benzoic acid (860595-98-8)

Conditions	Yield
at -15℃; sowie bei 20grad;

phthalic anhydride (85-44-9) + 1,1,1,2-tetrachoroethane (630-20-6) + 1,3-Dichlorobenzene (541-73-1) → 3,3-bis-(2,4-dichloro-phenyl)-phthalide

diethyl ether (60-29-7) + 1,1,1,2-tetrachoroethane (630-20-6) → chloroethane (75-00-3)

Conditions	Yield
at 250 - 290℃; in Gegenwart von Aluminiumoxyd oder -phosphat enthaltenden Katalysatoren unter Druck;

methyl chlorosulfate (812-01-1) + 1,1,1,2-tetrachoroethane (630-20-6) + 3-hydroxy-N-(4-methylphenyl)naphthalene-2-carboxamide (3651-62-5) → 2-hydroxy-3-p-tolylcarbamoyl-naphthalene-1-sulfonic acid

Conditions	Yield
at 100 - 110℃; beim nachfolgenden Erwaermen mit verd. Sodaloesung;

ethanol (64-17-5) + 1,1,1,2-tetrachoroethane (630-20-6) → chloroethane (75-00-3)

Conditions	Yield
in Gegenwart von Katalysatoren bei erhoehter Temperatur;

1,1,1,2-tetrachoroethane (630-20-6) + 5,11-naphthacenequinone (52755-65-4) → 6,12-dichloro-6,12-dihydro-naphthacene-5,11-dione (858456-17-4)

Conditions	Yield
Einleiten von Chlor;

1,1,1,2-tetrachoroethane (630-20-6) + chrysene (218-01-9) → 2-(chrysene-6-carbonyl)-benzoic acid (408311-76-2)

Conditions	Yield
at 20 - 75℃;
at 20 - 75℃;

1,1,1,2-tetrachoroethane (630-20-6) + N-tosyl-1-naphthylamine (18271-17-5) → N-(2,4-dichloro-[1]naphthyl)-toluene-4-sulfonamide (858005-74-0)

Conditions	Yield
at 50℃; beim Chlorieren;
at 50℃; beim Chlorieren;

1,1,1,2-tetrachoroethane (630-20-6) + 4,6-dichloro-2-methyl-6-nitro-1-nitryloxy-cyclohexa-2,4-dienol → 3-chloro-6-hydroxy-5-methyl-6-nitryloxy-cyclohexa-2,4-dienone

1,1,1,2-tetrachoroethane (630-20-6) + chloro-nitro-phenyl-acetic acid amide (861560-61-4) → dichloro-phenyl-acetic acid amide (7598-13-2)

Conditions	Yield
at 140℃;

1,1,1,2-tetrachoroethane (630-20-6) + N-[1]naphthyl-naphthalene-2-sulfonamide (303755-60-4) → N-(4-chloro-[1]naphthyl)-naphthalene-2-sulfonamide

Conditions	Yield
at 50℃; beim Chlorieren;

1,1,1,2-tetrachoroethane (630-20-6) + N-(4-chloro-[1]naphthyl)-toluene-4-sulfonamide (858005-76-2) → N-(2,4-dichloro-[1]naphthyl)-toluene-4-sulfonamide (858005-74-0)

Conditions	Yield
at 50℃; beim Chlorieren;
at 50℃; beim Chlorieren;

1,1,1,2-tetrachoroethane (630-20-6) + 2-methyl-5-nitro-benzenesulfonic acid-[1]naphthylamide (108981-71-1) → 2-methyl-5-nitro-benzenesulfonic acid-(4-chloro-[1]naphthylamide) (858005-86-4)

Conditions	Yield
at 50℃; beim Chlorieren;

1,1,1,2-tetrachoroethane (630-20-6) + 4,5,6-trichloro-2-methyl-6-nitro-1-nitryloxy-cyclohexa-2,4-dienol → 2,3-dichloro-6-hydroxy-5-methyl-6-nitryloxy-cyclohexa-2,4-dienone

1,1,1,2-tetrachoroethane (630-20-6) + 4,5,6-tribromo-2-methyl-6-nitro-1-nitryloxy-cyclohexa-2,4-dienol → 2,3-dibromo-6-hydroxy-5-methyl-6-nitryloxy-cyclohexa-2,4-dienone

1,1,1,2-tetrachoroethane (630-20-6) + 4,5-dichloro-2-methyl-6,6-dinitro-1-nitryloxy-cyclohexa-2,4-dienol → 2,3-dichloro-6-hydroxy-5-methyl-6-nitryloxy-cyclohexa-2,4-dienone

1,1,1,2-tetrachoroethane (630-20-6) + sodium ethanolate (141-52-6) → (E)-1,2-dichloro-1-ethoxy-ethene (42345-82-4)

Upstream product

• 50361-05-2 trans-2-chlorovinyldichloroarsine 
• 10026-13-8 phosphorus pentachloride 
• 64038-44-4 trans-2-chloro-vinylarsonic acid 
• 10025-87-3 trichlorophosphate 
• 505-60-2 bis (2-chloroethyl) sulphide 
• 7782-50-5 chlorine 
• 7647-01-0 hydrogenchloride 
• 7446-70-0 aluminium trichloride 
• 79-01-6 Trichloroethylene 
• 75-34-3 1,1-dichloroethane 
• 75-88-7 1,1,1-trifluoro-2-chloroethane 
• 67-72-1 hexachloroethane 
• 75-35-4 1,1-Dichloroethylene 
• 597-35-3 diethylsulfone 

Downstream Products

• 408311-76-2 2-(chrysene-6-carbonyl)-benzoic acid 
• 858005-74-0 N-(2,4-dichloro-[1]naphthyl)-toluene-4-sulfonamide 
• 7598-13-2 dichloro-phenyl-acetic acid amide 
• 858005-86-4 2-methyl-5-nitro-benzenesulfonic acid-(4-chloro-[1]naphthylamide) 
• 42345-82-4 (E)-1,2-dichloro-1-ethoxy-ethene 
• 593-63-5 chloroacetylene 
• 75-88-7 1,1,1-trifluoro-2-chloroethane 
• 1649-08-7 1,2-dichloro-1,1-difluoroethane 
• 811-95-0 1,1,2-trichloro-1-fluoroethane 
• 75-35-4 1,1-Dichloroethylene 
• 79-01-6 Trichloroethylene 
• 76-14-2 1,2-dichloro-1,1,2,2-tetrafluoroethane 
• 76-13-1 1,1,2-Trichloro-1,2,2-trifluoroethane 
• 118-74-1 hexachlorobenzene 

Relevant articles and documents

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