63006-81-5Relevant academic research and scientific papers
CARBON DOIXIDE: A REAGENT FOR THE PROTECTION OF NUCLEOPHILIC CENTERS AND THE SIMULTANEOUS ACTIVATION OF ELECTROPHILIC ATTACK. PART II. A NEW SYNTHETIC METHOD FOR THE 1-SUBSTITUTION OF 1,2,3,4-TETRAHYDROISOQUINOLINES.
Katritzky, Alan R.,Akutagawa, Kunihiko
, p. 2571 - 2574 (1986)
Tetrahydroisoquinoline was converted into several 1-substituted derivatives by using carbon dioxide both for N-protection and to give an intermediate carbanion stabilizing group. t-Butyllithium was used as a lithating agent at the alpha-carbon atom of the secondary amino group.The resulting 1-substituted 1,2,3,4-tetrahydroisoquinoline-2-carboxylic acids underwent smooth acid-catalysed decarboxylation under mild conditions.
