630067-06-0

Basic information

• Product Name: 1,10-Phenanthroline-5-carboxylic acid
• Synonyms: 1,10-Phenanthroline-5-carboxylic acid;1,10-PHENANTHROLINE-5-CARBOXYLICACID630067-06-0
• CAS NO: 630067-06-0
• Molecular Formula: C₁₃H₈N₂O₂
• Molecular Weight: 224.06
• Product Categories: Electronic Chemicals
• Mol File: 630067-06-0.mol

Chemical Properties

• Melting Point: 335-337 °C (decomp)(Solv: methanol (67-56-1))
• Boiling Point: 467.2 °C at 760 mmHg
• Flash Point: 236.3 °C
• Appearance: /
• Density: 1.431
• Vapor Pressure: 1.57E-09mmHg at 25°C
• Refractive Index: 1.769
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.83±0.30(Predicted)
• CAS DataBase Reference: 1,10-Phenanthroline-5-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1,10-Phenanthroline-5-carboxylic acid(630067-06-0)
• EPA Substance Registry System: 1,10-Phenanthroline-5-carboxylic acid(630067-06-0)

Safety Data

• Hazardous Substances Data: 630067-06-0(Hazardous Substances Data)

Usage

Uses

Used in Coordination Chemistry:
1,10-Phenanthroline-5-carboxylic acid is used as a ligand for the formation of metal complexes, leveraging its ability to chelate with metal ions, which is crucial in various chemical and biological processes.
Used in Anticancer Research:
In the field of oncology, 1,10-Phenanthroline-5-carboxylic acid is used as a potential anticancer agent, being investigated for its capacity to interact with biological targets and exhibit antitumor activity.
Used in Inhibition of Metalloenzymes:
1,10-Phenanthroline-5-carboxylic acid serves as an inhibitor of metalloenzymes, which are enzymes that require metal ions for their catalytic activity. Its use in this capacity can have implications in the regulation of enzymatic processes.
Used in Research and Development of Fluorescent Probes for Metal Ions:
1,10-Phenanthroline-5-carboxylic acid is utilized in the development of fluorescent probes designed to detect and measure the presence of metal ions, which is vital for understanding metal ion dynamics in biological systems.
Used in Study of DNA-Binding Proteins:
1,10-Phenanthroline-5-carboxylic acid is applied in research aimed at understanding the interactions between DNA and proteins, which is fundamental to the comprehension of genetic regulation and the development of new therapeutic strategies.

InChI:InChI=1/C13H8N2O2/c16-13(17)10-7-8-3-1-5-14-11(8)12-9(10)4-2-6-15-12/h1-7H,(H,16,17)

Upstream product

• 1082-21-9 5-cyano-1,10-phenanthroline 

Downstream Products

• 4199-88-6 5-Nitro-1,10-phenanthroline 

Relevant articles and documents

ANTI-CANCER LEUCIN-RICH PEPTIDES AND USES THEREOF

The invention relates to a pharmaceutically acceptable composition for use in the treatment of cancer, the composition comprising one or more peptides having a sequence comprising the motif GLLxLLxLLLxAAG, wherein x is independently selected from arginine (R), histidine (H), lysine (K), aspartic acid (D) or glutamic acid (E), and one or more pharmaceutically acceptable excipients. The invention also relates to the peptides of the pharmaceutically acceptable composition, a kit comprising the pharmaceutically acceptable composition, nucleotides encoding the peptides and vectors expressing the peptides.