630067-33-3

Basic information

• Product Name: 3-(4-FLUOROPHENYL)DIHYDROFURAN-2,5-DIONE
• Synonyms: 3-(4-FLUOROPHENYL)DIHYDROFURAN-2,5-DIONE
• CAS NO: 630067-33-3
• Molecular Formula: C10H7FO3
• Molecular Weight: 194.1591832
• Mol File: 630067-33-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(4-FLUOROPHENYL)DIHYDROFURAN-2,5-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-FLUOROPHENYL)DIHYDROFURAN-2,5-DIONE(630067-33-3)
• EPA Substance Registry System: 3-(4-FLUOROPHENYL)DIHYDROFURAN-2,5-DIONE(630067-33-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 630067-33-3(Hazardous Substances Data)

Upstream product

• 58755-90-1 3-(4-fluorophenyl)-2,5-dihydrofuran-2,5-dione 
• 459-22-3 4-fluorophenylacetonitrile 

Relevant articles and documents

Asymmetric hydrogenation of maleic anhydrides catalyzed by Rh/bisphosphine-thiourea: efficient construction of chiral succinic anhydrides

Asymmetric hydrogenation of various 3-substituted maleic anhydrides catalyzed by Rh/bisphosphine-thiourea (ZhaoPhos) under mild conditions was successfully developed. A wide range of 3-alkyl and 3-aryl maleic anhydrides were hydrogenated well to provide the desired products 3-substituted succinic anhydrides in one hour with excellent results (full conversions, up to 99% yield, 99% ee, 3000 TON). Importantly, we developed a creative and efficient synthetic route to construct the key intermediate of the hypoglycemic drug mitiglinide through our catalytic system.