630087-82-0Relevant academic research and scientific papers
Synthesis of N-propargylphenelzine and analogues as neuroprotective agents
Ling, Lei,Urichuk, Liana J.,Sloley,Coutts, Ronald T.,Baker, Glen B.,Shan, Jacqueline J.,Pang, Peter K.T.
, p. 2715 - 2717 (2007/10/03)
A series of N1- and N2-propargylphenelzine derivatives and analogues (1-7) was synthesized. In addition to their activity as monoamine oxidase inhibitors, two of the compounds, N1- and N2-propargylphenelzines (3 and 6), were found to be potent at preventing DSP-4-induced noradrenaline (NA) depletion in mouse hippocampus, suggesting that they have neuroprotective properties.
