63010-69-5

Usage

Uses

Used in Pharmaceutical Industry:
ETHYL 1,4-DIHYDRO-8-FLUORO-4-OXOQUINOLINE-3-CARBOXYLATE is used as an intermediate for the synthesis of halogenated 4-quinolones with antiplasmodial activities. These quinolones are crucial in the development of new antimalarial drugs, as they target and inhibit the growth of Plasmodium parasites responsible for causing malaria. ETHYL 1,4-DIHYDRO-8-FLUORO-4-OXOQUINOLINE-3-CARBOXYLATE plays a significant role in advancing research and innovation in the pharmaceutical sector to combat this global health issue.

Upstream product

• 63010-68-4 diethyl [(2-fluoroanilino)methylidene]malonate 
• 348-54-9 2-Fluoroaniline 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 

Downstream Products

• 63010-70-8 8-Fluoro-4-hydroxyquinoline-3-carboxylic acid 
• 228725-44-8 N-[(4-chlorophenyl)methyl]-8-fluoro-4-hydroxy-3-quinolinecarboxamide 
• 56824-90-9 4-chloro-8-fluoro-quinoline-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Quinoline-3-carboxamide containing sulfones as liver X receptor (LXR) agonists with binding selectivity for LXRβ and low blood-brain penetration

A series of quinoline-3-carboxamide containing sulfones was prepared and found to have good binding affinity for LXRβ and moderate binding selectivity over LXRα. The 8-Cl quinoline analog 33 with a high TPSA score, displayed 34-fold binding selectivity for LXRβ over LXRα (LXRβ IC50 = 16 nM), good activity for inducing ABCA1 gene expression in a THP macrophage cell line, desired weak potency in the LXRα Gal4 functional assay, and low blood-brain barrier penetration in rat.

TRIAZOLE COMPOUNDS AS LIPOXYGENASE INHIBITORS

There is provided compounds of formula (I) wherein W is an optionally substituted aryl or heteroaryl group, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a lipoxygenase (e.g. 15- lipoxygenase) is desired and/or required, and particularly in the treatment of inflammation.

Synthesis of fluoro-4-hydroxyquinoline-3-carboxylic acids by the Gould-Jacobs reaction

The synthesis of several fluoro-4-hydroxyquinoline-3-carboxylic acids by the Gould-Jacobs reaction is presented. These quinolines are important intermediates for the preparation of antibacterial fluoroquinolones.