63010-69-5

Basic information

• Product Name: ETHYL 1,4-DIHYDRO-8-FLUORO-4-OXOQUINOLINE-3-CARBOXYLATE
• Synonyms: BUTTPARK 18\09-67;ETHYL 1,4-DIHYDRO-8-FLUORO-4-OXOQUINOLINE-3-CARBOXYLATE;ETHYL 8-FLUORO-4-HYDROXY-3-QUINOLINECARBOXYLATE;ETHYL 8-FLUORO-4-HYDROXYQUINOLINE-3-CARBOXYLATE;ETHYL 8-FLUORO-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLATE;8-FLUORO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER;3-(Ethoxycarbonyl)-8-fluoro-4-hydroxyquinoline, 3-(Ethoxycarbonyl)-8-fluoro-4-hydroxy-1-azanaphthalene
• CAS NO: 63010-69-5
• Molecular Formula: C₁₂H₁₀FNO₃
• Molecular Weight: 235.21
• Product Categories: Acids and Derivatives;Heterocycles
• Mol File: 63010-69-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 205 °C
• Boiling Point: 338.5±37.0 °C(Predicted)
• Appearance: /
• Density: 1.353±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 6.28±0.41(Predicted)
• CAS DataBase Reference: ETHYL 1,4-DIHYDRO-8-FLUORO-4-OXOQUINOLINE-3-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 1,4-DIHYDRO-8-FLUORO-4-OXOQUINOLINE-3-CARBOXYLATE(63010-69-5)
• EPA Substance Registry System: ETHYL 1,4-DIHYDRO-8-FLUORO-4-OXOQUINOLINE-3-CARBOXYLATE(63010-69-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• Hazardous Substances Data: 63010-69-5(Hazardous Substances Data)

Usage

Uses

Ethyl 8-Fluoro-4-hydroxyquinoline-3-carboxylate is an intermediate used to prepare halogenated 4-quinolones with antiplasmodial activities.

Upstream product

• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 348-54-9 2-Fluoroaniline 
• 63010-68-4 diethyl [(2-fluoroanilino)methylidene]malonate 

Relevant articles and documents

Quinoline-3-carboxamide containing sulfones as liver X receptor (LXR) agonists with binding selectivity for LXRβ and low blood-brain penetration

A series of quinoline-3-carboxamide containing sulfones was prepared and found to have good binding affinity for LXRβ and moderate binding selectivity over LXRα. The 8-Cl quinoline analog 33 with a high TPSA score, displayed 34-fold binding selectivity for LXRβ over LXRα (LXRβ IC50 = 16 nM), good activity for inducing ABCA1 gene expression in a THP macrophage cell line, desired weak potency in the LXRα Gal4 functional assay, and low blood-brain barrier penetration in rat.

Synthesis of fluoro-4-hydroxyquinoline-3-carboxylic acids by the Gould-Jacobs reaction

The synthesis of several fluoro-4-hydroxyquinoline-3-carboxylic acids by the Gould-Jacobs reaction is presented. These quinolines are important intermediates for the preparation of antibacterial fluoroquinolones.