63010-71-9

Basic information

• Product Name: 8-FLUORO-4-HYDROXYQUINOLINE
• Synonyms: BUTTPARK 19\09-63;4-HYDROXY-8-FLUOROQUINOLINE;8-FLUORO-4-QUINOLINOL;8-FLUORO-4-HYDROXYQUINOLINE;8-FLUOROQUINOLIN-4-OL;8-Fluoro-4-hydroxyquinazoline;8-fluoroquinazolin-4(3H)-one;8-Fluoroquinolin-4-ol, 8-Fluoro-4-hydroxy-1-azanaphthalene
• CAS NO: 63010-71-9
• Molecular Formula: C₉H₆FNO
• Molecular Weight: 163.15
• Product Categories: Heterocycles;Quinoline&Isoquinoline;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Quinolines;QuinolinesHeterocyclic Building Blocks
• Mol File: 63010-71-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 260°C
• Boiling Point: 258.9oC at 760 mmHg
• Flash Point: 110.4oC
• Appearance: /
• Density: 1.291g/cm3
• Vapor Pressure: 0.0134mmHg at 25°C
• Refractive Index: 1.571
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 8.06±0.30(Predicted)
• CAS DataBase Reference: 8-FLUORO-4-HYDROXYQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-FLUORO-4-HYDROXYQUINOLINE(63010-71-9)
• EPA Substance Registry System: 8-FLUORO-4-HYDROXYQUINOLINE(63010-71-9)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-41
• Safety Statements: 26
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 63010-71-9(Hazardous Substances Data)

Usage

General Description

8-Fluoro-4-hydroxyquinoline is a chemical compound with the molecular formula C9H6FNO and a molecular weight of 159.15 g/mol. It is a derivative of quinoline and contains a fluorine atom and a hydroxyl group attached to the quinoline ring. This chemical is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It exhibits antimicrobial and antifungal properties, and its structure makes it a potential candidate for the development of new drugs. 8-Fluoro-4-hydroxyquinoline is also used in the production of dyes, pigments, and other specialty chemicals. It is important to handle this chemical with proper care, as it may pose health hazards if not used and stored appropriately.

InChI:InChI=1/C9H6FNO/c10-7-3-1-2-6-8(12)4-5-11-9(6)7/h1-5H,(H,11,12)

Upstream product

• 2033-24-1 cycl-isopropylidene malonate 
• 348-54-9 2-Fluoroaniline 
• 369395-32-4 5-[(2-fluoro-phenylamino)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione 
• 71083-06-2 ethyl 8-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate 

Downstream Products

• 63010-72-0 4-chloro-8-fluoro-quinoline 
• 927800-38-2 4-bromo-8-fluoroquinoline 
• 1033810-03-5 4-(2-chloro-4-nitrophenoxy)-8-fluoroquinoline 

Relevant articles and documents

Cu(I)-Catalyzed Alkynylation of Quinolones

Herein we report the first alkynylation of quinolones with terminal alkynes under mild reaction conditions. The reaction is catalyzed by Cu(I) salts in the presence of a Lewis acid, which is essential for the reactivity of the system. The enantioselective version of this transformation has also been explored, and the methodology has been applied in the synthesis of the enantioenriched tetrahydroquinoline alkaloid cuspareine.

Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities

A simple two-step synthesis method was used to make 51 B-ring-substituted 4-hydroxyquinolines allowing analysis of the effect of ring substitutions on inhibition of growth of chloroquine sensitive and resistant strains of Plasmodium falciparum, the dominant cause of malaria morbidity. Substituted quinoline rings other than the 7-chloroquinoline ring found in chloroquine were found to have significant activity against the drug-resistant strain of P. falciparum W2.