PD 168077 MALEATE is a selective dopamine D4 receptor agonist with a Ki value of 8.7 nM in CHO Pro 5 cells expressing the human receptor. It demonstrates high selectivity for dopamine D4 over D2 and D3 receptors, as well as other receptor subtypes such as α1and α2-adrenergic and serotonin (5-HT) receptors 5-HT1A and 5-HT2A. PD 168077 MALEATE has been shown to induce CaMKII translocation in primary rat embryonic prefrontal cortex pyramidal neurons and can elicit penile erections in rats when injected into the paraventricular nucleus of the hypothalamus. Additionally, it increases spontaneous locomotor activity and reduces grooming and rearing in rats.
630117-19-0
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Basic information
- Product Name: PD 168077 MALEATE
- Synonyms: N-(METHYL-4-(2-CYANOPHENYL)PIPERAZINYL)-3-METHYLBENZAMIDE MALEATE;PD 168077 MALEATE;N-[[4-(2-CYANOPHENYL)-1-PIPERAZINYL]METHYL]-3-METHYL-BENZAMIDE MALEATE
- CAS NO:630117-19-0
- Molecular Formula: C24H26N4O5
- Molecular Weight: 450.49
- EINECS: N/A
- Product Categories: N/A
- Mol File: 630117-19-0.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: white/powder
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: Desiccate at -20°C
- Solubility: DMSO: >10 mg/mL
- CAS DataBase Reference: PD 168077 MALEATE(CAS DataBase Reference)
- NIST Chemistry Reference: PD 168077 MALEATE(630117-19-0)
- EPA Substance Registry System: PD 168077 MALEATE(630117-19-0)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: 22-24/25
- WGK Germany: 3
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 630117-19-0(Hazardous Substances Data)
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630117-19-0 Usage
Uses
Used in Pharmaceutical Industry:PD 168077 MALEATE is used as a selective dopamine D4 receptor agonist for the development of potential therapeutic agents targeting the dopamine D4 receptor. Its high selectivity and specific actions on neuronal processes make it a valuable compound for research and drug development in the treatment of various neurological and psychiatric disorders.
Used in Neuroscience Research:
PD 168077 MALEATE is used as a research tool in neuroscience to study the role of dopamine D4 receptors in various brain functions and disorders. Its ability to induce CaMKII translocation and elicit specific behavioral responses in animal models makes it a useful compound for investigating the underlying mechanisms of dopamine D4 receptor-mediated actions.
Used in Drug Discovery and Development:
PD 168077 MALEATE is used in drug discovery and development as a lead compound for the design and synthesis of novel dopamine D4 receptor agonists. Its unique selectivity and pharmacological properties can guide the development of new drugs with improved efficacy and reduced side effects for the treatment of neurological and psychiatric disorders.
Biological Activity
A potent D 4 dopamine receptor agonist (K i = 8.7 nM) with > 400-fold selectivity over D 2 and > 300-fold selectivity versus D 3 subtypes respectively. Induces synaptic translocation of CaMK II to postsynaptic sites in cultured prefrontal cortical neurons. Centrally active in vivo .Check Digit Verification of cas no
The CAS Registry Mumber 630117-19-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,3,0,1,1 and 7 respectively; the second part has 2 digits, 1 and 9 respectively.Calculate Digit Verification of CAS Registry Number 630117-19:
(8*6)+(7*3)+(6*0)+(5*1)+(4*1)+(3*7)+(2*1)+(1*9)=110
110 % 10 = 0
So 630117-19-0 is a valid CAS Registry Number.
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630117-19-0Downstream Products
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PD 168077 MALEATE
