63013-17-2

Upstream product

• 63013-14-9 2-((4-methylbenzoyl)amino)-2-phenylacetic acid 
• 2835-06-5 phenylglycin 
• 874-60-2 4-methyl-benzoyl chloride 

Downstream Products

• 85653-74-3 C₂₂H₁₃⁽²⁾H₅N₂O₃ 
• 110699-07-5 2-Phenyl-5-p-tolyl-1H-pyrrole-3-carbaldehyde 
• 110699-05-3 4-Phenyl-2-p-tolyl-4-(1-p-tolyl-1H-[1,2,3]triazol-4-ylmethyl)-4H-oxazol-5-one 
• 110699-10-0 4-Methyl-N-(2-morpholin-4-yl-2-oxo-1-phenyl-ethyl)-benzamide 
• 110699-00-8 4-[1-(4-Chloro-phenyl)-1H-[1,2,3]triazol-4-ylmethyl]-4-phenyl-2-p-tolyl-4H-oxazol-5-one 
• 128732-17-2 4-Phenyl-4-(3-phenyl-isoxazol-4-ylmethyl)-2-p-tolyl-4H-oxazol-5-one 
• 128732-22-9 4-[3-(4-Methoxy-phenyl)-isoxazol-4-ylmethyl]-4-phenyl-2-p-tolyl-4H-oxazol-5-one 
• 128732-26-3 N-(5-Formyl-2-oxo-3,6-diphenyl-1,2,3,4-tetrahydro-pyridin-3-yl)-4-methyl-benzamide 
• 128732-29-6 3,4-dihydro-5-(hydroxymethyl)-3-(4-methoxybenzamido)-3,5-diphenyl-2(1H)-pyridone 
• 1115264-41-9 4-(2-nitro-1-phenylethyl)-4-phenyl-2-p-tolyloxazol-5(4H)-one 
• 1426830-24-1 ethyl 4-phenyl-2-(p-tolyl)-1H-imidazole-5-carboxylate 

Relevant academic research and scientific papers

Catalytic Aerobic Cross-Dehydrogenative Coupling of Azlactones en Route to α,α-Disubstituted α-Amino Acids

We developed a catalytic aerobic method to synthesize α,α-disubstituted α-amino acids through cross-dehydrogenative coupling of azlactones. Combining an iron catalyst with a bisoxazolidine ligand resulted in high catalytic performance, and cross-coupling with an indole proceeded smoothly under aerobic conditions. A wide variety of α-aryl and aliphatic amino acid derived azlactones were applied to the present catalysis. In addition, a quaternary carbon could be constructed using oxindole and benzofuranone under aerobic conditions.

Enantioselective iridium catalyzed α-alkylation of azlactones by a tandem asymmetric allylic alkylation/aza-Cope rearrangement

The development of an iridium catalyzed enantioselective α-alkylation of azlactones has been described. The reaction provides rapid access to a wide range of enantio-enriched quaternary carbon center allylated 2,4-diaryloxazol-5(2H)-ones in excellent yiel

Synthesis of di- and tri-substituted imidazole-4-carboxylates via PBu3-mediated [3+2] cycloaddition

Some new di- and trisubstituted imidazole-4-carboxylates were prepared from amidoacetic acids 3 in the present report. The key step to establish such imidazole- 4-carboxylates stemmed from the PBu3-mediated [3+2] cycloaddition between in situ-generated Δ2-oxazolinone 4 and ethyl cyanoformate6. Our results indicated that trisubstituted imidazoles 7-20 were afforded in better yields than those of disubstituted imidazoles 21-27. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications1 to view the free supplemental file. Copyright Taylor & Francis Group, LLC.

υ-Triazolines, XXVIII. - Reactions of 1-Aryl-4,5-dihydro-4-methylene-5-morpholino-υ-triazoles with 2,4-Diaryl-5(4h)-oxazolones

The 5(4H)-oxazolones 1a-d with an electron-rich aryl substituent on C-2 react with 4,5-dihydro-υ-triazoles 2a-c to afford the 4--5(4H)-oxazolones 3a-i as main reaction products and 2,5-diaryl-3-pyrrolecarbaldehydes 4a-d and glycine di

REACTION BETWEEN Δ2-OXAZOLIN-5-ONES AND NITROSOBENZENE. FORMATION OF 1,2,4-OXADIAZOLINES

2,4-diphenyl- and 2-p-methylphenyl-4-phenyl-Δ2-oxazolin-5-ones react at 80-110 deg C with nitrosobenzene to give benzamidines.However, reactions conducted at room temperature afford in high yield, the heretofore undescribed Δ4-oxadiazolin-3-carboxylic acids by regiospecific 1,3-dipolar cycloaddition.Thermal decomposition of the oxadiazolinecarboxylic acids gives the corresponding benzamidines.