630133-04-9

Upstream product

• 630132-97-7 methyl 2-(benzylamino)-2-(pyridin-2-yl)acetate 
• 100-46-9 benzylamine 
• 52458-81-8 methyl 2-bromo-2-(pyridin-2-yl) acetate 
• 872359-12-1 (7-hydroxy-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)-acetic acid 

Relevant academic research and scientific papers

A highly efficient, asymmetric synthesis of benzothiadiazine-substituted tetramic acids: Potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase

(Chemical Equation Presented) An efficient two-pot, asymmetric synthesis of benzothiadiazine-substituted tetramic acids is reported. Starting from commercially available α-amino acids or esters, reductive amination followed by a novel one-pot amide bond formation/Dieckmann cyclization provided the desired products in high yield and optical purity. An analogous solid-phase approach to the same targets is also presented. These compounds were found to be potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase.

NOVEL ANTI-INFECTIVES

Compounds useful as HCV anti-infectives are disclosed. Also disclosed are methods of making and using the same.