63014-77-7

Upstream product

• 6273-90-1 N-phenacyl-2-chloropyridinium bromide 
• 109-77-3 malononitrile 

Downstream Products

• 1133220-64-0 2-(2-naphthyl)-4-phenylpyrido[2,3-b]indolizine-10-carbonitrile 
• 1133220-54-8 2,4-diphenylpyrido[2,3-b]indolizine-10-carbonitrile 
• 1133220-90-2 2,4-diphenylpyrido[2,,-b]indolizine-10-carboxamide 
• 1133220-60-6 2-(p-bromophenyl)-4-phenylpyrido[2,3-b]indolizine-10-carbonitrile 

Relevant academic research and scientific papers

Cascade synthesis of pyrido[3,2-a]indolizines by reaction of Kr?hnke-Mukaiyama salts with malononitrile dimer

An efficient protocol for the synthesis of highly functionalized 2-aminoindolizines and pyrido[3,2-a]indolizines has been achieved via the reaction of N-RC(O)CH2-2-chloropyridinium bromides with 2-amino-1,1,3-tricyanopropene in the presence of Et3N. The reaction of N-allyl-2-chloropyridinium bromide with 2-amino-1,1,3-tricyanopropene in the presence of Et3N gives 3-[1-allylpyridin-2(1H)-ylidene]-2-aminoprop-1-ene-1,1,3-tricarbonitrile, which could be cyclized to give [2-amino-(2-amino-3-vinylindolizin-1-yl)methylene]malononitrile upon treatment with KOH-DMF.

Synthesis of 1-(1-aroyl-2-arylvinyl)-2-dicyanomethylen-1,2-dihydropyridines from 2-chloropyridinium salts and unsaturated nitriles

1-(1-Aroyl-2-arylvinyl)-2-dicyanomethylene-1,2-dihydropyridines are formed from 1-(aroylmethyl)-2-chloropyridinium bromides and arylmethylenemalonitriles in ethanol at room temperature in the presence of a twofold excess of triethylamine. The products are converted into 2-amino-3-aroyl-1-cyanoindolizines on boiling in acetic acid.