63015-10-1

Basic information

• Product Name: Androstenone hydrazone
• Synonyms: Androstenone hydrazone;Androst-5-en-17-one, 3β-hydroxy-, hydrazone;Dehydroepiandrosterone-17-hydrazone;3beta-Hydroxy-androst-5-en-17-one hydrazone;(3S,8R,9S,10R,13S,14S,E)-17-hydrazono-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
• CAS NO: 63015-10-1
• Molecular Formula: C₁₉H₃₀N₂O
• Molecular Weight: 302.4543
• EINECS: -0
• Product Categories: Intermediate of Abiraterone Acetate
• Mol File: 63015-10-1.mol
• Article Data: 21

Chemical Properties

• Melting Point: 242-244℃
• Boiling Point: 462.5±55.0 °C(Predicted)
• Appearance: /
• Density: 1.30±0.1 g/cm3(Predicted)
• PKA: 15.01±0.60(Predicted)
• CAS DataBase Reference: Androstenone hydrazone(CAS DataBase Reference)
• NIST Chemistry Reference: Androstenone hydrazone(63015-10-1)
• EPA Substance Registry System: Androstenone hydrazone(63015-10-1)

Safety Data

• Hazardous Substances Data: 63015-10-1(Hazardous Substances Data)

Usage

General Description

Androstenone hydrazone is a chemical compound that belongs to the class of hydrazones and is derived from androstenone, a steroid hormone associated with male pheromones. It has been identified as a pheromone derivative that plays a role in mammalian olfactory signaling and is believed to be involved in the regulation of mating behavior and social interactions. Androstenone hydrazone has been studied for its potential applications in the development of pheromone-based products and is also of interest in the field of chemical ecology for its role in animal communication and behavior. Furthermore, it is a subject of ongoing research in the field of neurobiology and neuroendocrinology to better understand its effects on the brain and behavior.

Upstream product

• 53-43-0 dehydroepiandrosterone 
• 853-23-6 prasterone acetate 
• 53-43-0 dehydroepiandrosterone 

Downstream Products

• 32138-69-5 17-Iodandrosta-5,16-dien-3β-ol 
• 154229-21-7 17-(3-pyridine)-4,16-dieneandrost-3-one 
• 154229-18-2 abiraterone acetate 
• 154229-19-3 abiraterone 
• 32138-69-5 17-iodo-5,16-androstadien-3-ol 
• 86770-60-7 17,17-diiodo-3β-hydroxy-5-androstene 
• 91414-16-3 3β-hydroxy-17-phenylselenoandrosta-5,16-diene 
• 53-43-0 dehydroepiandrosterone 
• 114474-49-6 17-bromo-3β-hydroxy-17-selenophenylandrost-5-ene 

Relevant articles and documents

Synthesis, characterization and antitumor activities of some steroidal derivatives with side chain of 17-hydrazone aromatic heterocycle

Here a series of dehydroepiandrosterone-17-hydrazone and estrone-17-hydrazone derivatives possessing various aromatic heterocycle structures in 17-side chain of their steroidal nucleus were synthesized and their structures were evaluated. The antiproliferative activity of synthesized compounds against some cancer cells was investigated. The results have demonstrated that some dehydroepiandrosterone-17-hydrazone derivatives show distinct antiproliferative activity against some cancer cells through inducing cancer cell apoptosis, and compound 8 with a quinoline structure in 17-side chain displays excellent antiproliferative activity in vitro against SGC 7901 cancer cell (human gastric carcinoma) with an IC50 value of 1 μM. In addition, estrone-17-hydrazone derivatives having a key feature of indole group in the structure showed a special obvious cytotoxicity against HeLa cells, but almost inactive against other cells. The information obtained from the studies is valuable for the design of novel steroidal chemotherapeutic drugs.

Discovery of novel isatin-dehydroepiandrosterone conjugates as potential anticancer agents

A series of isatin-dehydroepiandrosterone hybrids were synthesised via a convenient condensation procedure, and which were evaluated for their potential anticancer activities. The preliminary assays indicated that some of the newly obtained compounds exhi

Dimerization androst compound and its preparation method, pharmaceutical composition and application

Dimeric androstane type compounds shown as the formula (I) are disclosed. Definitions of R1 and R2 are described in the specification. A preparing method, a pharmaceutical composition and applications of the dimeric androstane type compounds are further disclosed.

Compound with anti-tumor activity and application of compound

The invention discloses an amino-acid-oriented steroid small peptide compound with anti-tumor activity.The structure of the compound is shown in the general formula I.Corresponding hydrazone and oxime are synthesized with dehydroepiandrosterone (DHEA), DHEA and an amino acid derivative are then condensed, and the compound is obtained.The compound has a remarkable inhibiting effect on growth of tumor cells especially human hepatoma cells, human lung cancer cells and human melanoma cells, and can serve as an active ingredient for anti-tumor medicine to be applied to prevention and treatment of cancer.