6303-40-8Relevant articles and documents
Synthesis and Evaluation of some 2-, 4- and 2,4-Di-substituted-6-methylpyrimidine Derivatives for Antimicrobial Activity
Ghoneim, Khadiga M.,El-Telbany, Farag,Youssef, Khairia
, p. 914 - 917 (2007/10/02)
The reaction of 2-amino-4-chloro-, 4-amino-2-chloro- and 2,4-dichloro-6-methylpyrimidines with primary aromatic amines under acidic conditions is presented. 2-, and 4-ω-substituted-thioureido-6-methylpyrimidines were synthesised via the reaction of 2-amino- and 4-amino-6-methylpyrimidine derivatives with arylisocyanates.Six compounds were evaluated for their antimicrobial activity and most of them showed a moderate activity against B.subtilis, E. coli and A. niger.