6303-65-7

Basic information

• Product Name: bicyclo[2.2.2]octane-2,3-dicarbonitrile
• CAS NO: 6303-65-7
• Molecular Formula: C₁₀H₁₂N₂
• Molecular Weight: 160.2157
• Mol File: 6303-65-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 346.8°C at 760 mmHg
• Flash Point: 171.5°C
• Density: 1.09g/cm³
• Vapor Pressure: 5.61E-05mmHg at 25°C
• Refractive Index: 1.513
• CAS DataBase Reference: bicyclo[2.2.2]octane-2,3-dicarbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: bicyclo[2.2.2]octane-2,3-dicarbonitrile(6303-65-7)
• EPA Substance Registry System: bicyclo[2.2.2]octane-2,3-dicarbonitrile(6303-65-7)

Safety Data

• Hazardous Substances Data: 6303-65-7(Hazardous Substances Data)

Upstream product

• 6343-19-7 bicyclo[2.2.2]oct-5-ene-2,3-dicarbonitrile 
• 24425-59-0 endo-cis-2,3-Dicyano-bicyclo<2.2.2>octen-(5) 

Relevant articles and documents

Synthesis, biophysical studies, and antiproliferative activity of platinum(II) complexes having 1,2-bis(aminomethyl)carbobicyclic ligands

A selected chemical library of six platinum(II) complexes having 1,2-bis(aminomethyl)carbobicyclic ligands were synthesized after a rational design in order to evaluate their antiproliferative activity and the structure-activity relationships. The cytotoxicity studies were performed using cancer cell lines sensitive (A2780) and resistant (A2780R) to cisplatin. Excellent cytotoxicity was observed for most of complexes, which presented better resistance factors than cisplatin against the A2780R cell line. The interaction of these complexes with DNA, as the target biomolecule, was evaluated by several methods: DNA-platinum binding kinetics, changes in the DNA melting temperature, evaluation of the unwinding angle of supercoiled DNA, evaluation of the interstrand cross-links, and replication mapping. The kinetics of the interaction with glutathione was also investigated to better understand the resistant factors observed for the new complexes.