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6303-65-7

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6303-65-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 6303-65-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,3,0 and 3 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 6303-65:
(6*6)+(5*3)+(4*0)+(3*3)+(2*6)+(1*5)=77
77 % 10 = 7
So 6303-65-7 is a valid CAS Registry Number.

6303-65-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name bicyclo[2.2.2]octane-2,3-dicarbonitrile

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6303-65-7 SDS

6303-65-7Downstream Products

6303-65-7Relevant articles and documents

Synthesis, biophysical studies, and antiproliferative activity of platinum(II) complexes having 1,2-bis(aminomethyl)carbobicyclic ligands

De Mier-Vinué, Jordi,Gay, Marina,Monta?a, ángel M.,Sáez, Rosa-Isabel,Moreno, Virtudes,Kasparkova, Jana,Vrana, Oldrich,Heringova, Pavla,Brabec, Viktor,Boccarelli, Angela,Coluccia, Mauro,Natile, Giovanni

, p. 424 - 431 (2008/09/19)

A selected chemical library of six platinum(II) complexes having 1,2-bis(aminomethyl)carbobicyclic ligands were synthesized after a rational design in order to evaluate their antiproliferative activity and the structure-activity relationships. The cytotoxicity studies were performed using cancer cell lines sensitive (A2780) and resistant (A2780R) to cisplatin. Excellent cytotoxicity was observed for most of complexes, which presented better resistance factors than cisplatin against the A2780R cell line. The interaction of these complexes with DNA, as the target biomolecule, was evaluated by several methods: DNA-platinum binding kinetics, changes in the DNA melting temperature, evaluation of the unwinding angle of supercoiled DNA, evaluation of the interstrand cross-links, and replication mapping. The kinetics of the interaction with glutathione was also investigated to better understand the resistant factors observed for the new complexes.

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