63035-27-8

Basic information

• Product Name: 1-(tetrahydrofuran-2-ylcarbonyl)-1,4-diazepane
• Synonyms: 1-(tetrahydrofuran-2-ylcarbonyl)-1,4-diazepane;AKOS BBV-010914;UKRORGSYN-BB BBV-010914;1-(tetrahydrofuran-2-ylcarbonyl)-1,4-diazepane(SALTDATA: FREE)
• CAS NO: 63035-27-8
• Molecular Formula: C10H18N2O2
• Molecular Weight: 198.26
• Mol File: 63035-27-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 369.751°C at 760 mmHg
• Flash Point: 177.42°C
• Appearance: /
• Density: 1.112g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.502
• CAS DataBase Reference: 1-(tetrahydrofuran-2-ylcarbonyl)-1,4-diazepane(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(tetrahydrofuran-2-ylcarbonyl)-1,4-diazepane(63035-27-8)
• EPA Substance Registry System: 1-(tetrahydrofuran-2-ylcarbonyl)-1,4-diazepane(63035-27-8)

Safety Data

• Hazardous Substances Data: 63035-27-8(Hazardous Substances Data)

Usage

Structure

Six-membered heterocycle with a nitrogen atom and a tetrahydrofuran ring substituted with a carbonyl group

Application

Commonly used in the synthesis of pharmaceuticals and agrochemicals

Potential use

Antiepileptic drug due to its ability to modulate neuronal excitability

Additional therapeutic potential

Treatment of anxiety and depression

Biological activities

Exhibits various biological activities

Interest in medicinal chemistry

Potential as a therapeutic agent

InChI:InChI=1/C10H18N2O2/c13-10(9-3-1-8-14-9)12-6-2-4-11-5-7-12/h9,11H,1-8H2

Upstream product

• 16874-33-2 tetrahydro-2-furancarboxylic acid 
• 61903-13-7 [1,4]Diazepan-1-yl-furan-2-yl-methanone 

Relevant articles and documents

2-thioquinazolinedione derivatives

The invention belongs to the field of medicine and chemical industry, and in particular, relates to 2-thioquinazolinedione derivatives and a use thereof in drugs. Specifically, the invention relates to compounds having the use of inhibiting poly(ADP-ribose) polymerase activity, wherein the enzyme is also known as poly(ADP-ribose) synthetase and polyADP-ribosyltransferase, and is commonly known as PARP. The compounds have the following characteristics described in the specification. In the compounds represented by the formula (I), A and D together represent substituted fused aromatic rings; X can be NRX or CRXRY; if X is NRX, n is 1 or 2; if X is CRXRY, n is 1; RX can be selected from H, substitutive C1-20 alkyl, C5-20 aryl, C3-20 heterocyclic group, amide, thioamide, ester, acyl and sulfonyl; RY is selected from H, hydroxyl, amino and the like; or RX and RY can together form a spiro-C3-7 cyclic hydrocarbon group or a heterocyclic group; R2 and R3 are both H, or when X=CRXRY, R2, R3, RX, and RY and carbon atoms connected therewith can form a substitutive fused aromatic ring; and R1 is selected from H or halogen.