630392-71-1

Basic information

• Product Name: Phosphorodiamidic acid, N,N-bis(2-chloroethyl)-, (4-nitrophenyl)methyl ester
• CAS NO: 630392-71-1
• Molecular Formula: C11H16Cl2N3O4P
• Molecular Weight: 356.145
• Mol File: 630392-71-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Phosphorodiamidic acid, N,N-bis(2-chloroethyl)-, (4-nitrophenyl)methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphorodiamidic acid, N,N-bis(2-chloroethyl)-, (4-nitrophenyl)methyl ester(630392-71-1)
• EPA Substance Registry System: Phosphorodiamidic acid, N,N-bis(2-chloroethyl)-, (4-nitrophenyl)methyl ester(630392-71-1)

Safety Data

• Hazardous Substances Data: 630392-71-1(Hazardous Substances Data)

Upstream product

• 127-88-8 N,N-di(2-chloroethyl)amidophosphoric acid dichloride 
• 619-73-8 4-nitrobenzyl chloride 

Downstream Products

• 10159-53-2 phosphoramide mustard 

Relevant articles and documents

Nitroaryl Phosphoramides as Novel Prodrugs for E. coli Nitroreductase Activation in Enzyme Prodrug Therapy

Cyclic and acyclic nitroaryl phosphoramide mustard analogues were activated by E. coli nitroreductase, an enzyme explored in GDEPT. The more active acyclic 4-nitrobenzyl phosphoramide mustard (7) showed 167 500x selective cytotoxicity toward nitroreductase-expressing V79 cells with an IC50 as low as 0.4 nM. This is about 100x more active and 27x more selective than CB1954 (1). The superior activity was attributed to its better substrate activity (kcat/Km 19x better than 1) and/or excellent cytotoxicity of phosphoramide mustard released.

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