630414-70-9

Usage

Uses

Used in Pharmaceutical Synthesis:
8-(benzyloxy)quinoline-7-carboxylic acid serves as a key building block in the synthesis of various pharmaceuticals. Its unique structure and properties contribute to the development of new drugs with potential therapeutic applications.
Used in Organic Compounds Synthesis:
In the field of organic chemistry, 8-(benzyloxy)quinoline-7-carboxylic acid is utilized as an intermediate for synthesizing a range of organic compounds. Its reactivity and structural features facilitate the creation of diverse chemical entities for various applications.

Upstream product

• 1101929-86-5 C₁₈H₁₅NO₃ 
• 73776-20-2 8-hydroxyquinoline-7-carboxylic acid methyl ester 
• 19829-79-9 8-hydroxy-7-quinolinecarboxylic acid 
• 908255-30-1 8-benzyloxyquinoline-7-carboxylic acid benzyl ester 

Downstream Products

• 1101929-87-6 C₁₇H₁₂FNO₂ 
• 1392440-36-6 8-(benzyloxy)-N-(4-fluorobenzyl)quinoline-7-carboxamide 
• 1392440-06-0 7-((4-fluorobenzyl)carbamoyl)-8-hydroxyquinoline 1-oxide 
• 1101929-88-7 C₆₀H₄₈N₆O₁₂ 
• 630414-71-0 C₅₉H₅₄N₆O₄ 

Relevant academic research and scientific papers

Oxinobactin and sulfoxinobactin, abiotic siderophore analogues to enterobactin involving 8-hydroxyquinoline subunits: Thermodynamic and structural studies

The synthesis of two new iron chelators built on the tris-l-serine trilactone scaffold of enterobactin and bearing a 8-hydroxyquinoline (oxinobactin) or 8-hydroxyquinoline-5-sulfonate (sulfoxinobactin) unit has been described. The X-ray structure of the ferric oxinobactin has been determined, exhibiting a slightly distorted octahedral environment for Fe(III) and a Δ configuration. The Fe(III) chelating properties have been examined by potentiometric and spectrophotometric titrations in methanol-water 80/20% w/w solvent for oxinobactin and in water for sulfoxinobactin. They reveal the extraordinarily complexing ability (pFeIII values) of oxinobactin over the p[H] range 2-9, the pFe value at p[H] 7.4 being 32.8. This was supported by spectrophotometric competition showing that oxinobactin removes Fe(III) from ferric enterobactin at p[H] 7.4. In contrast, the Fe(III) affinity of sulfoxinobactin was largely lower as compared to oxinobactin but similar to that of the ligand O-TRENSOX having a TREN backbone. These results are discussed in relation to the predisposition by the trilactone scaffold of the chelating units. Some comparisons are also made with other quinoline-based ligands and hydroxypyridinonate ligand (hopobactin).

HIV INTEGRASE INHIBITORS

Provided herein, inter alia, are novel compounds for the inhibition of HIV integrase. The compounds disclosed herein are useful for methods of treating HIV infection in a subject in need thereof.

Oxinobactin, a siderophore analogue to enterobactin involving 8-hydroxyquinoline subunits: Synthesis and iron binding ability

Oxinobactin, a siderophore analogue to enterobactin but possessing 8-hydroxyquinoline instead of catechol complexing subunits, has been synthesized starting from l-serine and 8-hydroxyquinoline. Comparative iron binding studies showed that oxinobactin is as effective as enterobactin for the complexation of FeIII at physiological pH but with improved complexing ability at acidic pH.

Synthesis and biological evaluation of purine derivatives incorporating metal chelating ligands as HIV integrase inhibitors

Because of its essential role in HIV replication and lack of human counterpart, HIV integrase is an attractive target for the development of novel anti-AIDS agents. Among the recently developed integrase inhibitors, only the α,γ-diketo acid (DKA) compound