6305-66-4Relevant academic research and scientific papers
A new 3-hydroxyphthalimide-based turn-on fluorescent probe for Hg2+ detection in aqueous solution
Hu, Sheng-Li,Li, Qiao,Pan, Xue-Tao,Xu, Yuan-Yuan
, p. 349 - 353 (2020/02/06)
A new 3-hydroxyphthalimide-based turn-on fluorescent probe is designed and synthesized. This probe can be used to determine the presence of Hg2+ ions by fluorescence spectroscope with high selectivity over other metal ions in aqueous solution. The analytical detection limit for Hg2+ is as low as 6.5 × 10?7 M. The recognition mechanism is attributed to Hg2+-promoted carbonothioate group cleavage and a subsequent excited-state intramolecular proton transfer mechanisms.
A novel ESIPT-based fluorescent chemodosimeter for Hg2+ detection and its application in live-cell imaging
Huang, Jing,Chen, Bo,Zhou, Baocheng,Han, Yifeng
supporting information, p. 1181 - 1186 (2018/02/06)
A new excited-state intramolecular proton transfer (ESIPT) based fluorescent chemodosimeter for the detection of Hg2+ has been rationally designed and developed. The probe operates via the specific mercury-promoted desulfurization reaction of thiophthalimide to phthalimide and exhibits high selectivity and sensitivity in an almost pure aqueous solution (containing only 1% DMSO) with a low detection limit of 1.5 ppb. Furthermore, the probe was successfully used for the fluorescence imaging of Hg2+ in live cells.
A new ESIPT-based fluorescent probe for highly selective and sensitive detection of hydrogen sulfide and its application in live-cell imaging
Chen, Bo,Huang, Jing,Geng, Huiqing,Xuan, Lingli,Xu, Tengfei,Li, Xin,Han, Yifeng
, p. 1119 - 1123 (2017/02/10)
A new excited-state intramolecular proton transfer (ESIPT) based fluorescent probe for the detection of hydrogen sulfide has been reasonably designed and developed. The probe operates by H2S-mediated reduction of hydroxylamine to amine and exhibits high selectivity and sensitivity under mild conditions. Furthermore, the probe was successfully used for fluorescence imaging of H2S in living cells.
New phthalimide-methionine dyad-based fluorescence probes for reactive oxygen species: Singlet oxygen, hydrogen peroxide, and hypochlorite
Griesbeck, Axel G.,?ngel, Banu,Atar, Murat
, (2017/08/23)
Different reactive oxygen species were detected by the molecular probes 1-3 that were composed of the phthalimide fluorophore as reporter and a methionine-derived thioether side-chain as receptor part. The sulfoxides that were formed as the primary oxidation products show strong fluorescence in the blue-green (430-540?nm) spectral region. Self-sensitized oxidation by singlet oxygen is in general inefficient indicating rapid electron-transfer quenching of the excited probe molecules. With hydrogen peroxide as thermal oxidant conversion to the sulfoxides is slow but can be accelerated by addition of titanium(IV) catalysts, whereas hypochlorite as oxidant behaves much more reactive even under uncatalyzed conditions. Singlet oxygen that is generated by energy transfer from the photosensitizer Rose Bengal was detected by sensor 1a with rate constants of >107M–1?s–1, a typical rate constant for the oxidation of thioethers to sulfoxides.
A selective and sensitive phthalimide-based fluorescent probe for hydrogen sulfide with a large Stokes shift
Yang, Liu,Liu, Xingjiang,Gao, Li,Qi, Fengpei,Tian, Huihui,Song, Xiangzhi
, p. 98154 - 98159 (2015/12/04)
A phthalimide-based fluorescent probe for hydrogen sulfide has been developed with high sensitivity and excellent selectivity. Upon treatment with hydrogen sulfide, this probe displays a strong fluorescence enhancement (196-fold) with a large Stokes shift (105 nm). Moreover, the potential application of using this probe in biological systems has been demonstrated by imaging hydrogen sulfide in living cells.
A phthalimide-based fluorescent probe for thiol detection with a large Stokes shift
Liu, Xingjiang,Gao, Li,Yang, Liu,Zou, Lifen,Chen, Wenqiang,Song, Xiangzhi
, p. 18177 - 18182 (2015/05/04)
A phthalimide-based dye, probe 1, was developed as a novel fluorescent probe for thiol detection with excellent selectivity and high sensitivity based on the combination of photo induced electron transfer (PET) and excited state intramolecular proton transfer (ESIPT) mechanisms. The probe can detect thiols quantitatively and selectively with a large Stokes shift (161 nm) and the detection limit (S/N = 3) is as low as 0.8 nM. Furthermore, this probe was successfully used for imaging thiols in living SH-SY5Y cells.
A phthalimide-based fluorescent probe for thiophenol detection in water samples and living cells with a large Stokes shift
Liu, Xingjiang,Yang, Liu,Gao, Li,Chen, Wenqiang,Qi, Fengpei,Song, Xiangzhi
, p. 8285 - 8289 (2015/10/05)
A phthalimide-based fluorescent probe for the detection of thiophenol was developed based on the combination of photo-induced electron transfer (PET) and excited-state intramolecular proton transfer (ESIPT) mechanisms. This probe displays high sensitivity
