6306-69-0

Usage

Type

Methylxanthine derivative

Bronchodilator

Relaxes smooth muscles of the bronchioles in the lungs, making it easier to breathe.

Anti-inflammatory

Reduces inflammation in the airways.

Central nervous system stimulant

Stimulates the central nervous system.

Heart function improvement

Enhances heart function.

Asthma treatment

Helps in managing asthma symptoms.

Chronic bronchitis treatment

Alleviates symptoms of chronic bronchitis.

Emphysema treatment

Improves lung function in patients with emphysema.

Heart disease treatment

Effective in treating certain types of heart disease.

Precautions

Should be used with caution and under the supervision of a healthcare professional due to potential adverse effects.

InChI:InChI=1/C15H16N6O3/c1-19-11-12(20(2)15(24)21(3)13(11)23)17-14(19)18-16-8-9-6-4-5-7-10(9)22/h4-8,16H,1-3H3,(H,17,18)/b9-8+

Upstream product

• 53703-63-2 8-hydrazino-1,3,7-trimethyl-3,7-dihydropurine-2,6-dione 
• 90-02-8 salicylaldehyde 
• 4921-49-7 8-chlorocaffeine 
• 58-08-2 3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione 

Relevant academic research and scientific papers

Caffeine-hydrazones as anticancer agents with pronounced selectivity toward T-lymphoblastic leukaemia cells

We report design and synthesis of set of novel anticancer agents based on caffeine-hydrazones bearing 2-hydroxyaryl- or 2-N-heteroaryl moiety. Anticancer activity evaluation using seven cancer cell lines and two non-malignant cell lines demonstrated that several derivatives display significant anticancer activity and great selectivity index toward T-lymphoblastic leukaemia cells. In general, hydrazones bearing 2-N-heteroaryl moiety are more active and selective than those with 2-hydroxyaryl moiety. Tested compounds exhibit dose-dependent inhibition of both RNA and DNA synthesis, with some exceptions. Antimicrobial activities were tested on set of twelve bacterial and yeast strains, however prepared compounds were not active, suggesting for a molecular target specific for eukaryotic cells.