6306-71-4

Usage

Uses

Used in Pharmaceutical Industry:
Lobendazole is used as an anthelmintic agent for the treatment of various parasitic worm infections, such as hookworm, roundworm, whipworm, and pinworm. It is effective against both adult and larval stages of these parasites, making it a versatile choice for treating a wide range of helminthic infections.
Used in Veterinary Medicine:
In addition to its use in human medicine, Lobendazole is also used as a veterinary drug for treating and preventing parasitic infections in animals, such as cattle, sheep, and pigs. It helps to maintain the health of livestock by controlling the spread of parasitic worms, which can cause significant economic losses in the agricultural industry.
Used in Research and Development:
Lobendazole is also utilized in research settings to study the biology and life cycle of parasitic worms. Its anthelmintic properties make it a valuable tool for understanding the mechanisms of worm infections and for developing new treatments and strategies to combat these parasites.

InChI:InChI=1/C10H11N3O2/c1-2-15-10(14)13-9-11-7-5-3-4-6-8(7)12-9/h3-6H,2H2,1H3,(H2,11,12,13,14)

Upstream product

• 52938-06-4 1-Ethoxycarbonyl-2-amino-benzimidazol 
• 95-54-5 1,2-diamino-benzene 
• 5585-23-9 N-(ethoxythiocarbonyl)urethane 
• 934-32-7 1H-benzimidazol-2-amine 
• 64-17-5 ethanol 
• 10605-21-7 N-(2-benzimidazolyl)-O-methyl carbamate 
• 27079-30-7 1-(2-aminophenyl)-3-ethoxycarbonyl-2-thiourea 

Downstream Products

• 934-32-7 1H-benzimidazol-2-amine 

Relevant academic research and scientific papers

The giardicidal activity of lobendazole, fabomotizole, tenatoprazole and ipriflavone: A ligand-based virtual screening and in vitro study

A ligand-based virtual screening study to search for giardicidal compounds on a 6551 ChEMBL drugs database was carried out using molecular similarity. Three fingerprints implemented in MayaChemTools with different design and validated by ROC curves, were used. Twelve compounds were retrieved from this screening, from which, four representative compounds were selected to carry out biological assays. Whereas two compounds were commercially available, the additional two compounds were synthesized during the development of this work. The biological assays revealed that the compounds possess in vitro activity against five strains of Giardia intestinalis, each with different susceptibility/resistance rates to metronidazole, albendazole and nitazoxanide. Particularly, tenatoprazole showed the best effect against the WB and IMSS strains. Furthermore, fabomotizole, tenatoprazole and ipriflavone showed a higher activity against resistant strains than the reference drugs: metronidazole, albendazole and nitazoxanide.

Phosphonium-mediated cyclization of N-(2-aminophenyl)thioureas: Efficient synthesis of 2-aminobenzimidazoles

BOP efficiently promoted the phosphonium-mediated cyclization of thioureas, leading to a convenient synthesis of 2-aminobenzimidazoles. Compared to conventional methods, the reactions were complete at room temperature with times ranging from a few minutes