63071-13-6

Basic information

• Product Name: 4-CHLOROPICOLINALDEHYDE
• Synonyms: 4-CHLOROPICOLINALDEHYDE;4-CHLOROPYRIDINE-2-CARBOXALDEHYDE;4-Chloro-2-pyridinecarboxaldehyde;4-chloro-2-pyridinecarbaldehyde;4-chloropyridine-2-carbaldehyde;4-Chloropyridin-2-ylcarboxaldehyde;2-Pyridinecarboxaldehyde,4-chloro-;Picolinaldehyde, 4-chloro-
• CAS NO: 63071-13-6
• Molecular Formula: C₆H₄ClNO
• Molecular Weight: 141.56
• Product Categories: Pyridines
• Mol File: 63071-13-6.mol
• Article Data: 15

Chemical Properties

• Melting Point: 32-34°
• Boiling Point: 206℃
• Flash Point: 79℃
• Appearance: /
• Density: 1.332
• Vapor Pressure: 0.24mmHg at 25°C
• Refractive Index: 1.592
• Storage Temp.: Refrigerated.
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 1.78±0.10(Predicted)
• Stability: Air Sensitive
• CAS DataBase Reference: 4-CHLOROPICOLINALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLOROPICOLINALDEHYDE(63071-13-6)
• EPA Substance Registry System: 4-CHLOROPICOLINALDEHYDE(63071-13-6)

Safety Data

• Statements: 43
• Safety Statements: 36/37
• HazardClass: IRRITANT
• Hazardous Substances Data: 63071-13-6(Hazardous Substances Data)

Usage

Uses

4-Chloro-2-pyridinecarboxaldehyde is a useful synthetic intermediate. It is used in the synthesis of 2,2''-bipyridines, (chloropyridyl)(pyridyl)ethylamine and aryl and heteroaryl fluoromethyl ketones.

InChI:InChI=1/C6H4ClNO/c7-5-1-2-8-6(3-5)4-9/h1-4H

Upstream product

• 24484-93-3 4-Chloro-pyridine-2-carboxylic acid methyl ester 
• 98-98-6 2-Picolinic acid 
• 53750-66-6 4-chloro-pyridine-2-carbonyl chloride 
• 7379-35-3 4-chlorpyridine hydrochloride 
• 696-08-2 4-chloro-2-picoline-N-oxide 
• 3678-63-5 4-chIoro-2-methylpyridine 
• 63071-10-3 (4-chloropyridin-2-yl)methanol 

Downstream Products

• 1421236-80-7 (R)-N-((1R,2R)-3-((S)-4-benzyl-5,5-dimethyl-2-oxooxazolidin-3-yl)-1-(4-chloropyridin-2-yl)-2-methyl-3-oxopropyl)-2-methylpropane-2-sulfinamide 

Relevant articles and documents

DINUCLEATING LIGAND OR DINUCLEAR METAL COMPLEX

To provide a dinuclear metal complex that can be synthesized simply and easily and has a proper anticancer action.SOLUTION: The present disclosure provides a dinucleating ligand represented by the following formula (I) and a dinuclear metal complex thereof (where each X may be the same or different to represent H, Cl, OMe, or, Me, Y is H, a phenyl group, a substituted carbamoyl group or the like).SELECTED DRAWING: None

A Transition-Metal-Free One-Pot Cascade Process for Transformation of Primary Alcohols (RCH2OH) to Nitriles (RCN) Mediated by SO2F2

A new transition-metal-free one-pot cascade process for the direct conversion of alcohols to nitriles was developed without introducing an “additional carbon atom”. This protocol allows transformations of readily available, inexpensive, and abundant alcohols to highly valuable nitriles.

NOVEL MORPHOLINE DERIVATIVE OR SALT THEREOF

There is provided a morpholine derivative represented by General Formula [1A] or a salt thereof. (In the formula, a ring A represents a ring represented by General Formula [I]; * represents a bonding position; Z2 represents CH or the like; Z1 represents CR6 or the like; R6 represents a hydrogen atom or the like; X1 represents CHR7 or the like; R7 represents a hydrogen atom or the like; X2 represents CH2 or the like; R1 and R2 are the same as or different from each other, and each of R1 and R2 represents a hydrogen atom or the like; R3, R4, and R5 are the same as or different from each other, and each of R3, R4, and R5 represents a hydrogen atom, NRaRb, or the like; and each of Ra and Rb represents a hydrogen atom, a C1-8 alkyl group which may have a substituent, or the like.)