63075-64-9

Basic information

• Product Name: diethyl 4-hydroxybutylphosphonate
• Synonyms: diethyl 4-hydroxybutylphosphonate
• CAS NO: 63075-64-9
• Molecular Formula: C8H19O4P
• Molecular Weight: 210.207821
• Mol File: 63075-64-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: diethyl 4-hydroxybutylphosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl 4-hydroxybutylphosphonate(63075-64-9)
• EPA Substance Registry System: diethyl 4-hydroxybutylphosphonate(63075-64-9)

Safety Data

• Hazardous Substances Data: 63075-64-9(Hazardous Substances Data)

Upstream product

• 928-51-8 4-Chloro-1-butanol 
• 122-52-1 triethyl phosphite 
• 32421-69-5 diethyl 4-acetoxy-n-butylphosphonate 
• 63075-66-1 diethyl (4-bromobutyl)phosphonate 
• 38694-48-3 γ-diethoxyphosphorylbutyric acid 
• 117345-78-5 diethyl 4-(tert-butyldimethylsilyloxy)butanephosphonate 
• 15916-48-0 diethyl but-3-en-1-ylphosphonate 

Downstream Products

• 158957-14-3 3-formyl-1-propylphosphonic acid diethyl ester 
• 174538-67-1 {4-[5-(3-Benzoyl-2-methyl-isothioureido)-4-carbamoyl-[1,2,3]triazol-1-ylmethoxy]-butyl}-phosphonic acid diethyl ester 
• 174538-64-8 {4-[5-(3-Benzoyl-thioureido)-4-carbamoyl-[1,2,3]triazol-1-ylmethoxy]-butyl}-phosphonic acid diethyl ester 
• 174538-52-4 {4-[5-(3-Benzoyl-2-methyl-isothioureido)-4-carbamoyl-[1,2,3]triazol-1-yl]-butyl}-phosphonic acid diethyl ester 
• 174538-49-9 {4-[5-(3-Benzoyl-thioureido)-4-carbamoyl-[1,2,3]triazol-1-yl]-butyl}-phosphonic acid diethyl ester 

Relevant articles and documents

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A series of new 9-(4-phosphonobutoxy)purines was synthesized and evaluated as antiviral agents. 9-(4-Phosphonobutoxy)guanine displayed potent and selective activity against HIV-1 in peripheral blood lymphocytes.

Polymer electrolyte membrane based on polyacrylate with phosphonic acid via long alkyl side chains

A series of novel phosphonated polymers with phosphonic acid groups via different lengths of flexible pendant side chains was synthesized. The radical polymerization of the corresponding diethyl esters of acrylate monomers, followed by hydrolysis with trimethylsilyl bromide produced the expected polyacrylates. Among the three polymers, the cross-linked poly[6-(acryloyloxy) hexylphosphonic acid] (PAHPA) membrane prepared by the recombination of polymer radicals with benzoyl peroxide as a radical initiator showed excellent proton conductivity comparable to that of the Nafion 117 membrane in the range of 30-80% relative humidity (RH) at 80 °C, regardless of the significant low water uptake behavior. Furthermore, well-defined phase separation between the hydrophobic and hydrophilic domains was clearly observed by scanning transmission electron microscopy (STEM) and synchrotron X-ray scattering measurements. To the best of our knowledge, the cross-linked PAHPA membrane shows the best proton conductivity performance among phosphonated polymers already reported. The Royal Society of Chemistry 2013.

Glucose compound, medicinal composition and application thereof

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Phosphonate acyclic derivatives of guanines, pyrazolo[3,4-d]pyrimidines, and triazolo[4,5-d]-pyrimidines (8-azaguanines) are inhibitors of the enzyme purine nucleoside phosphorylase (PNPase) with K′1 values ranging from 0.05 to 1.6 μM. These compounds are enzymatically stable congeners of the potent PNPase inhibitor acyclovir diphosphate (53).

Antiviral phosphonylalkoxy purines

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